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Pharmaceutical, Drugs, Fine Chemicals, Bulk Drug Intermediates, Pharmaceutical Drugs, Pharma Drug Ingredients Intermediates, Drug Intermediates, Speciality Chemicals, Raw Materials, Fine and Specialty Chemicals Intermediates, Pharmaceutical Bulk Drugs

Indian drugs and pharmaceutical industry has advanced perceptibly and is getting ready  for the new patent regime and  to withstand global competition, which is expected to be unleashed by new winds of liberalisation - a new era of liberalisation - much different from what was ushered in since the conclusion of the Uruguay Round and the establishment of the World Trade Organisation.

The industry has been expanding at annual rates ranging between 8 to 10% (against global growth rate of 6%).  According to a study  by McKinsey, Vision 2010, the domestic pharmaceutical industry could attain a size of  $25 billion (Rs 1200 billion) by 2010 by focusing on two areas: first, innovation-led research, development and new drug discoveries; and second, information technology-led remote sales and marketing.  The market for bulk drugs and formulations had increased from about Rs 103  billion in 1990-91 to an estimated Rs 435  billion at the end of 2003-04.  The prices of Indian essential drugs are among the lowest in the world. Apart from strides made by the industry in the last half-a-century, lower production cost due to reverse engineering and low R&D outlays has been a major factor in keeping the prices under check.

The global pharmaceutical industry is estimated at $ 300 billion, not all representing cross-border trade.  India's measly share of $ 1.5 billion in global trade represents an untapped potential. Under the regime of economic liberalisation underway since early 1990s, the drugs and pharmaceutical sector witnessed initiatives at fresh investment in the sector. Nearly 1735 investment proposals of the order of around Rs 166  billion were initiated. The foreign collaboration proposals approved numbered around 425 with a foreign direct investment  (FDI) component of over Rs 25 billion. The pharmaceuticals have figured high on the export front. In 2001-02,  the sector was  estimated to have registered a growth of 17.6% at around Rs 20.3 billion.

In the wake of economic liberalisation, many a  overseas players  returned or contemplated returning to India. These include Ivox Corp (USA),  Taro Pharmaceuticals (Israel) and Merck (USA). These are out either to set shop or looking for acquisitions in India. Hexal AG of Germany has established a liaison office in India. MILLIONCs like Rocha, Bayer, Aventis and Chiron are making India a regional hub for bulk drugs. 

The Export Import Bank of India (Exim Bank) had  doubled its corpus for the pharmaceutical industry to Rs 2 billion as a result of increased activity in the industry, especially in the external sector. The fund is used for the development and commercialisation of the new products and applications, significant improvement in the existing design of  products, setting up and expansion of pilot plants, research studies for obtaining regulatory approvals, cost of filing and managing international patent and R&D Centres.

It needs, however, to be recognised that the presence  of small scale manufacturers has resulted, on the one hand,  in a highly fragmented industry, and on the other, it has made it possible to supply a near 100,000 drugs including vitamins, antibiotics, antibacterials, cardio-vascular and other essential drugs. These account for nearly 37% of the market.  While each of about 80% of the manufacturers has annual sales below a billion rupees, top ten companies are known to control over 30% of the market. At present there are more than 20,000 players in the country.

The major players are: Alembic Chem, Aurobindo Pharma, Cipla, Dr. Reddy's, FDC, IPCA Labs, Jagsonpal Pharma, J.B. Chemicals, Kopran, Lupin Labs, Lyka Labs, Morepan Labs, Nicholas Piramal, Ranbaxy Labs, Sun Pharma, Themis Medicare, GlaxoSmithkline, Astrazeneca, Aventis, E-Merck, Torrent Pharma, TTK Healthcare, Unichem Labs,  Wockhardt  and  Zandu Pharma.  Until recently, only a few of the Indian companies had gone into any serious R&D activity. Much of the effort was directed to affordable analogue research. The R&D level in the country is low with even well-placed pharma companies spending less than 2% of turnover on R&D. MILLIONCs are known to contribute as much as 10% or more of their turnover to R&D.  While India is very strong in process chemistry, biology and applied bio-chemistry, initiatives at all levels - government, academia, private sector - involving heavy financial outlays, are called for.

Ayurveda continues to remain a preferred system of medicine for a vast segment of population in the country. The country has over 400,000 registered practitioners of the Indian system of medicine. Around 170 institutes properly affiliated to various universities impart under- or post-graduate courses each year. These institutes churn out some 5,500 fresh practitioners. The practitioners are supported by 12,000 dispensaries and 2,100 beds available for ayurveda treatment countrywide. The emerging biotechnology sector has already taken by storm and is offering sops to states to make these as the thriving ground for the highly potential segment in medicare.

How to Prepare Project Report on Pharmaceutical Processing Industry?

Drug manufacturing companies work under strict laws and regulations. Their processes need to comply with relevant drugs act in their respective countries.

Therefore, if you are planning to invest in pharmaceutical processing, a good project report will be necessary. Besides the prominent aspects of a project report, you should pay close attention to the following issues in a pharmaceutical processing report.

1. Marketing

This industry is very competitive. I need not stress the value of detailed market analysis. You need to understand the status of market competition and the demand for pharmaceutical products. A proper market analysis will additionally help you prepare an excellent pharmaceutical business plan. Given your market analysis report, you will develop a marketing plan.

2. Government approval

In almost all countries, there are laws and regulations for the manufacture, distribution, and administration of drugs. Consider giving a status report on these requirements when making the final project status report.

3. Manufacturing Process

It would help if you had a picture of the process you will employ in making your drugs. Outline the quality checks and balances in the process. State the required pharmaceutical intermediates and their corresponding active pharmaceutical ingredients.

4. Machines and Equipment

You need to identify the equipment you will need, such as homogenizers, spectrophotometer, tabulating machines, etc. to ensure the machines meet quality specifications. You may also need to put down a plan to train workers on their operations.

How Does the Drug Manufacturing Process Work?

If you are an aspiring drug manufacturer, you should know how the bulk drug manufacturing process works. This is a complicated process and requires professional skills in molecular biology, medical microbiology, and pharmacy.

The process involves four steps, namely:

  • Milling
  • Granulation
  • Coating
  • Tabulation

Milling is important because it makes the drug powder uniform. It ensures uniform distribution of the active pharmaceutical ingredients. Additionally, milling makes it easier to formulate the drug into a syrup or emulsion.

After milling, you can use wet or dry granulation to form granules. You then coat them and compress the drugs using a tabulating machine. Alternatively, you can fill the granules into capsules.

For any chemical industry business ideas, prioritize the security of your staff. Ensure workers have sufficient PPEs. Have plans to protect them from chemical poisoning. Install eyewashes and emergency showers in both production units and laboratories.

Pre-Feasibility Report on Bulk Drug Manufacturing Process

Before you set up a feasibility report or start making a business plan, you first need to do a pre-feasibility study. It is the conclusions of this study that will make you decide whether to proceed to the project feasibility report or not.

Implementing a pharmacy business plan is an expensive affair. Please do not put any investment into a business plan of this magnitude without looking at its feasibility study report.

Considering the variety of pharmaceutical products, a feasibility plan will help you decide on the most relevant product for your target market. The results of pre-feasibility and feasibility studies will inform your marketing strategy plan. At the pre-feasibility stage, you get to review the technical skills required for the bulk drug manufacturing process. You also assess the knowledge level and determine whether you have the knowledge and skills.

Lastly, this report looks at the financial demands of a chemical project report on bulk drug processing. From here, you will decide on the feasibility of the project.

How to Grow Pharmaceutical Intermediates Market?

The pharmaceutical industry relies on pharmaceutical intermediates. We use these chemicals to produce active pharmaceutical ingredients (API). 

To grow the pharmaceutical intermediates market, therefore, we should focus on the drug manufacturing industry. Here are some tips on how we can grow this industry.

1. Investment in Research and Development

We should encourage governments and established drug manufacturers to invest in research and development of new medicines. New drug development will increase the need for pharmaceutical intermediates. Consequently, this will cause the growth of the industry.

2. Boost Generic Drug Manufacturing

Feasibility study reports for project ideas in pharmaceuticals show a growing demand for generics. This demand is particularly high in developing countries. More investment in generic drugs will result in increased demand for pharmaceutical intermediates.

3. Collaborations

It is quite expensive to run a pharmaceutical intermediate processing company. If you look at a project summary example for the local industry and you will notice the huge investment. One way of cushioning the industry is to encourage collaborations, mergers, and acquisitions. Working together gives small-scale companies a competitive advantage. It lowers their operation costs and improves revenue.

How to Set Up a Chemical Industry Business Plan?

Writing a chemical industry business plan begins with a pre-feasibility study. Here, you look at the various business ideas in chemical manufacturing. You then evaluate each of these ideas based on:

1. Skills and Knowledge

If you are interested in the chemical manufacturing industry, I assume that you have some skills or knowledge in this sector. If so, look at the skills required for each idea you have. Which of these ideas marches your skills and knowledge?

2. Financial Resources

Different chemical processes have different cost implications. Try to review each idea against the expected financial input. You can examine some business plan examples on the internet to get a hint on required inputs. Once you have a convincing pre-feasibility report, you can proceed to make a feasibility report meaning the idea is profitable and viable.

The next step in setting up a chemical industry business plan is to prepare a small business marketing plan. The results of your feasibility report will help do this.

Chemical manufacturing is not only expensive, but it is also strictly regulated by law. It would be best if you had an innovative marketing strategy to break even. It would be best if you did an accurate market analysis.

A project report on the pharmaceutical industry helps you assess the dynamics of the industry. You will want to know who the major chemical manufacturers are. You will also assess the availability of raw materials and machinery for your pharmaceutical industry.

In your project report, you will also address the technical aspects of the pharmaceutical manufacturing process. You need to draw a flow diagram for the process. Lastly, sit down and draw a business plan for your chemical industry business. You will need the information from all the above processes. Additionally, a business plan will consider the financial implications of your pharmaceutical industry project report.

We can provide you detailed project reports on the following topics. Please select the projects of your interests.

Each detailed project reports cover all the aspects of business, from analysing the market, confirming availability of various necessities such as plant & machinery, raw materials to forecasting the financial requirements. The scope of the report includes assessing market potential, negotiating with collaborators, investment decision making, corporate diversification planning etc. in a very planned manner by formulating detailed manufacturing techniques and forecasting financial aspects by estimating the cost of raw material, formulating the cash flow statement, projecting the balance sheet etc.

We also offer self-contained Pre-Investment and Pre-Feasibility Studies, Market Surveys and Studies, Preparation of Techno-Economic Feasibility Reports, Identification and Selection of Plant and Machinery, Manufacturing Process and or Equipment required, General Guidance, Technical and Commercial Counseling for setting up new industrial projects on the following topics.

Many of the engineers, project consultant & industrial consultancy firms in India and worldwide use our project reports as one of the input in doing their analysis.

We can modify the project capacity and project cost as per your requirement.
We can also prepare project report on any subject as per your requirement.

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Natural Glycerine - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

Glycerine (sometimes called ‘‘glycerin’’) is the name of the commercial product consisting of glycerol and a small amount of water. . At low temperatures, glycerine tends to supercool, rather than crystallize. Water solutions of glycerine resist freezing, a property responsible for glycerine's use as permanent antifreeze in cooling, systems. Among its most valuable attributes are hygroscopicity, or the ability to absorb moisture from the atmosphere, and low vapor pressure, a combination that produces outstanding permanent humectancy and plasticity. A prominent source of glycerine is from the sweetwaters of fat splitting. Applications in which glycerine's versatility as a chemical is exploited account for approximately half of the glycerine consumed by industry. The most important industrial class of derivatives is esters, which are formed by reacting glycerine with acids, usually at high temperatures. Among these are alkyd resins of long chain fatty acids. Uses and Applications Glycerine is a very good solvent for organic and inorganic substances e.g. phenols, borates, etc. Its strong hydrogen bonding properties have been suggested as an explanation for its very good solvent activity. Glycerine's chief role in a glue composition is that it acts as a plasticizer. Glycerine is used too in vegetable adhesives for labeling or as office pastes. In starch pastes, it is added as a plasticizer to give a more flexible bond, and should be incorporated as glycerite of starch. Glycerine is widely used in dextrin adhesives which are employed for bottle labeling, gumming envelope flaps and labels, book binding and carton sealing. . After the green plants are cut or picked, glycerine will help retain the bright appearance of decorative leaves or foliage. Market Survey As stated by the new market research report on Glycerin, Asia Pacific constitutes the largest regional market. Increased applications of glycerin in various sectors such as pharmaceuticals, personal care and food & beverages, coupled with lower import duties in the Chinese market is expected to boost demand for glycerin in the Asia Pacific region. Latin America is projected to register the fastest compounded annual growth rate of 6.75% over the analysis period. Worldwide consumption of refined glycerin is forecast to grow healthily in the coming few years. Global value demand for natural glycerine will grow 9.8% annually from the current manufacturing value of $7.7 billion in 2011 to $13.5 billion through 2017. Few Indian Major Players are as under: Adi Finechem Ltd. Godrej Consumer Products Ltd. Godrej Industries Ltd. Golden Agro Tech Inds. Ltd. Gujarat Godrej Innovative Chemicals Ltd. [Erstwhile] Jocil Ltd. Micron Chemicals Ltd. Nirma Ltd. Organic Chemoils Ltd. Raj Agro Mills Ltd. Ritesh International Ltd. Ruchi Soya Inds. Ltd. Southern Online Bio Technologies Ltd. Sree Rayalaseema Alkalies & Allied Chemicals Ltd. Tata Oil Mills Co. Ltd. Wipro Ltd.
Plant capacity: 50.0 MT/Day, Crude Fatty Acid by product : 30.0 MT/DayPlant & machinery: Rs.360 Lakhs
Working capital: -T.C.I: Cost of Project : Rs.2475 Lakhs
Return: 38.00%Break even: 33.00%
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Disposable Plastic Syringes - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

A syringe is a simple piston pump consisting of a plunger that fits tightly in a tube. The disposable plastic syringe has become an important part of the medical scene since its introduction in the late 1950's. It is an instrument which is used for injecting any liquid into the body of human beings or of animals. These syringes are used for injecting the medicine into the body or into the nerve of the body which are not possible to take in through mouth or takes much time in mixing with blood. Disposable syringes are mostly injection moulded from polypropylene. Plastic syringes are becoming more popular in the medical world due to its lower cost and higher accuracy. Uses & Applications Disposable syringes commonly are used in modern medicine for the injection of drugs and vaccines or for the extraction of blood. Among the common uses of disposable syringes are the injecting of insulin by a diabetic person and the administering of a local anesthesia by a dentist. Disposable syringes also are used to inject anesthetics for medical procedures. The syringes used by dentists to administer local anesthesia before drilling or pulling teeth are a common example. Disposable syringes sometimes are used for drawing blood samples. They also are used when blood is being drawn from a vessel very close to the skin, such as those in the wrists and hands. Market Survey Needles and syringes are amongst the most extensively used medical disposables. Healthcare professionals represent the largest end use market for syringes, followed by diabetics. A substantial rise in the number of drug addicts has also contributed to the enhanced demand for syringes across the world. Rising life expectancies and growing proportion of the elderly have led to increased demand for healthcare services, and greater need for drugs to be injected. Additionally, a number of newly introduced drugs including DNA based drugs are not available in the form of pills and must be administered intravenously, thereby enhancing the demand for disposable syringes. Worldwide market for syringes is driven by an aging population and related rise in healthcare demand. Other factors influencing growth include increasing popularity of pre filled syringes, rising incidence of diabetes, and growing awareness of AIDS and other infectious diseases. The growth in domestic demand may be conservatively expected to be 25% per annum, assuming constant export of 100 million syringes /year. There are many manufacturer of disposable syringes in the country, out of which about 5 6 units are under small scale sector. The total installed capacity is to be about 400 million and actual production is about 350 million. Few Indian Major Players are as under: Albert David Ltd. Disposable Medi Aids Ltd. H L L Lifecare Ltd. Hindustan Syringes & Medical Devices Ltd. Iscon Surgicals Ltd. La Medical Devices Ltd. Lifeline Injects Ltd. Lifelong Meditech Ltd. Nirma Ltd. Raaj Medisafe India Ltd. Sangam Health Care Products Ltd. Surgiplast Ltd. Cost Estimation Capacity Syringes (2 ml) :11,200.0 Nos./ Day Syringes (5 ml) :11,200.0 Nos./ Day Syringes (10 ml) :11,200.0 Nos./ Day
Plant capacity: -Plant & machinery: Rs.113 Lakhs
Working capital: -T.C.I: Cost of Project : Rs.288 Lakhs
Return: 27.00%Break even: 46.00%
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Soya Protein - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Soy protein is a protein that is isolated from soybean. It is made from soybean meal that has been dehulled and defatted. Soy protein is generally regarded as the storage protein held in discrete particles called protein bodies, which are estimated to contain at least 60 to 70% of the total soybean protein. The health benefits of soy protein powders are coming from the soy protein and the associated isoflavones. The soy protein has a high biological value and contains all essential amino acids. Soy isoflavones have been recognized for many health benefits, including lowering the risk of heart disease, breast cancer, prostate cancer and osteoporosis. Soy isoflavones act as anti cancer agents because they are antioxidant, inhibit the growth of blood vessels required to feed tumours and inhibit the protein production in cancer cells. Soy isoflavones are also beneficial for menopausal women because they may ease menopausal symptoms and help to maintain strong bones. Uses and Applications Soya Protein is used in Meat Products, Sea food Products, cereal products, dairy type products, infant formulas. Partially hydrolysed soy proteins possess good foam stabilization properties and can be used as whipping agents in combination with egg albumen or whole eggs in confectionery products and deserts. Isolated soybean protein has been shown to be an effective spray drying aid in fruit purees. In this application, it can replace maltodextrins, with the advantage of contributing protein to the final product. Market Survey This market is driven by the nutritive, functionally properties, and the health benefits achieved. The largest market for the soy protein ingredients is in the North American region, whereas Asia Pacific market is predictable to register best growth opportunities. Moreover, China and India will be the fastest growing country in global soy protein ingredients market as its strong economic growth continues. Latin America is the second fastest growing region and Brazil is the major market for soy protein ingredients. North America and European regions are expected to show moderate growth rate. Soy protein is becoming more prevalent in the world marketplace. Major crop and oilseed processors are recognizing this demand and developing products accordingly. India’s current and projected population levels and the state of the economy show the country is poised for a transition of diets that are higher in protein content. Few Indian Major Players are as under: Acropetal Technologies Ltd. Amar Remedies Ltd. Bliss G V S Pharma Ltd. Genomics Biotech Ltd. Indiaco Health Care Pvt. Ltd. Pan Herbo Ltd. Paramount Surgimed Ltd. Premier Proteins Ltd. Proline Technologies Ltd. Protchem Industries (India) Ltd.
Plant capacity: 10 MT/DayPlant & machinery: Rs.134 Lakhs
Working capital: -T.C.I: Cost of Project : Rs.522 Lakhs
Return: 34.00%Break even: 54.00%
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Active Pharma Ingredients(API) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

An active ingredient (AI) is the substance in a pharmaceutical drug or a pesticide that is biologically active. The similar terms active pharmaceutical ingredient (API) and bulk active are also used in medicine, and the term active substance may be used for pesticide formulations. Some medications and pesticide products may contain more than one active ingredient. A dosage form: the API, which is the drug itself; and an excipient, which is the substance of the tablet, or the liquid the API is suspended in, or other material that is pharmaceutically inert. Drugs are chosen primarily for their active ingredients. The Indian pharmaceutical industry also needs to take advantage of the recent advances in biotechnology and information technology. The future of the industry will be determined by how well it markets its products to several regions and distributes risks, its forward and backward integration capabilities, its R&D, its consolidation through mergers and acquisitions, co-marketing and licensing agreements. Uses and Applications API like Cephalexin is used to treat a number of infections including: otitis media, streptococcal pharyngitis, bone and joint infections, pneumonia, cellulitis, and urinary tract infections. It may be used to prevent bacterial endocarditis. Amoxicillin is used in the treatment of a number of infections, including acute otitis media, Streptococcal pharyngitis, pneumonia, skin infections, urinary-tract infections, Salmonella, lyme disease, and chlamydia infections. It is also used to prevent bacterial endocarditis in high-risk people who are having dental work done, to prevent strep pneumococus infections in those without spleens, and for both the prevention and the treatment of anthrax. Ibuprofen is used primarily for fever, pain, dysmenorrhea and inflammatory diseases such asrheumatoid arthritis. It is also used for pericarditis and patent ductus arteriosus. Market Survey The demand for pharmaceutical products in India is significant and is driven by low drug penetration, rising middle-class & disposable income, increased government & private spending on healthcare infrastructure, increasing medical insurance penetration etc. India based pharmaceutical companies are not only catering to the domestic market and fulfilling the country’s demands, they are also exporting to around 220 countries. They are exporting high quality, low cost drugs to countries such as the US, Kenya, Malaysia, Nigeria, Russia, Singapore, South Africa, Ukraine, Vietnam, and more. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. Few Major Players are as under:- Cipla Ranbaxy Lab Dr Reddy's Labs Sun Pharma Lupin Ltd Aurobindo Pharma Piramal Health Cadila Health Matrix Labs Wockhardt
Plant capacity: Cephalexin Monohydrate: 500 Kgs/Day, Ampicillin Trihydrate: 500 Kgs/Day,Ibuprofen: 500 Kgs/DayPlant & machinery: Rs.448 Lakhs
Working capital: -T.C.I: Cost Of Project : Rs.958 Lakhs
Return: 46.00%Break even: 44.00%
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Sterile Water for Injection - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

Sterilization is a term referring to any process that eliminates (removes) or kills all forms of microbial life, including transmissible agents (such as fungi, bacteria, viruses, spore forms, etc.) present on a surface, contained in a fluid, in medication, or in a compound such as biological culture media. Sterilization can be achieved by applying the proper combinations of heat, chemicals, irradiation, high pressure, and filtration. Sterile Products are dosage forms of therapeutic agents that are free of viable microorganisms. Sterile products are most frequently solution or suspensions, but may even be solid pellets for tissue implementation. The most frequently used vehicle for sterile products is water since it is the vehicle for all body products. Sterile water is water that has no microorganisms living within it. As it cannot transfer pathogens, it is used mainly in the medical setting. Sterile water, though sometimes distilled, is not the same thing as distilled water. As some microorganisms can survive at high temperatures, simply boiling water may not be enough to sterilize it. Special, but not uncommon, equipment is required if one wishes to sterilize water. Uses and Applications Sterile Water for Injection is indicated for use only as a solvent or diluents vehicle for parenterally administered drugs or solutions and as a source of water for parenteral fluid replenishment after suitable additives are introduced to avoid tonicity of the blood. In some cases, it may be used as a lavage or rinsing agent, but isotonic solutions suitable to the area of exposure are preferred if available. When administered intravenously as a vehicle for drugs, Sterile Water for Injection provides a source of water for parenteral fluid replenishment after proper osmolarity has been achieved. The osmolarity of the solution determines the direction of water flow into or out of the cell. In normal body situations, solute concentration within and outside the cell is isotonic. Market Survey Intravenous fluids injected into a patient’s vein either as a medium for other medicines or to relieve dehydration may soon get costlier as the drug price regulator is considering an upward revision in their prices—for the first time in eleven years. Four-fifths of patients admitted to a hospital require intravenous fluids regularly, making it an essential part of treatment as well as the hospital bill, according to medical practitioners. Intravenous fluids have a big market with an annual turnover of more than Rs 400 crore, which is growing at about 14% a year due to its essential nature. Some of the Asian countries are changing and becoming very competitive in biopharma manufacturing. Few Major Players are as under:- Albert David Ltd. Core Laboratories Ltd. [Merged] Lupin Laboratories Ltd. [Merged] Pure Pharma Ltd. Taulis Pharma Ltd.
Plant capacity: 100,000 Nos./Day Ampoules (5 ml size)Plant & machinery: Rs.36 Lakhs
Working capital: -T.C.I: Cost Of Project : Rs.148 Lakhs
Return: 37.00%Break even: 48.00%
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CALCIUM D SACCHARATE - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

INTRODUCTION It is the normal calcium salt of D-saccharic acid, a dicarboxylic sugar acid derived from the oxidation of D-gluconic acid. Calcium D-saccharate is a true chemical compound formerly called calcium saccharate and produced by the action of lime upon sugar. PROCESS Calcium D-glucarate is made by combining glucaric acid with calcium salt. Uses and Application Pharmaceutic aid (stabilizer for calcium gluconate solutions). As plasticizer in cement, concrete, mortar. It is used in medical application, used as dietary supplement. Calcium D saccharate is used as an anti-toxin, speeding the elimination of pesticides, carcinogens, estrogens and even steriods from the body. Calcium D-saccharate could conceivably reduce water retention (bloat), body fat and cancer risk by way of superior estrogen elimination. Properties Calcium D Saccharate is odorless, tasteless crystals or fine white powder. It is stable to air. Becomes anhydrous upon heating at 100° in vacuum. Practically, insoluble in water, alcohol, ether. Soluble in dilute mineral acids and in calcium gluconate solutions. Molecular Formula: C6H8CaO8 Molecular Weight: 248.20 Percent Composition: C 29.03%, H 3.25%, Ca 16.15%, O 51.57% Line Formula: CaC6H8O8 Indian produces around 260 metric tons per annum several unit produces Calcium D Saccharate in multi product facility.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: --
Return: 1.00%Break even: 1.00%
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Dextrose Powder - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Layout

Dextrose (or D-Glucose) is a simple hexose mono-saccharide sugar. It is the natural form of Glucose. Dextrose is offered at a very high grade of purity. Its empirical formula is C6H12O6. Dextrose is used as a source of energy to cultivate microorganisms and for fermentation studies. Dextrose is incorporated into many culture media formulae such as those employed in the selective isolation of enterobacteriaceae. Dextrose is obtained from starches or cellulose. The raw materials can be corn, rice potatoes or many other vegetables. Dextrose Monohydrate is the crystalline form of glucose it is a source of carbohydrate energy. Dextrose is commercially available in monohydrate or anhydrate form termed Dextrose Monohydrate or Dextrose Anhydrate respectively. Uses and Applications Dextrose can be used in food applications, pharmaceutical, chemical and animal feed. Dextrose is used in cold brines curing salts and meat maturing preparations. In dairy desserts dextrose can replace 10-15% of the sucrose without affecting flavor. In sauces it can be used to vary sweetness and taste perception. In ice cream, dextrose can lower the freezing point by twice the extent given by sucrose. It can be used in energy drinks being rapidly assimilated by micro organisms in the small intestine. It is also used as bulking agent and sweetener in powdered drinks. Due to its total ferment ability dextrose can be used as a priming agent in brewing. It is widely used in chewing gum as an enhancer of fruit flavors. In the production of tablets dextrose gives a fresh sensation because it dissolves pleasantly on the tongue. It provides excellent stable crunchiness with a pleasant cooling effect. Dextrose reduces sweetness while retaining energy value and glazing capacity. It is used as diluents for tablets and in rehydration salts to replenish water and mineral reserves. Dextrose can be used as a hydrophilic agent in the synthesis of biodegradable non-ionic surfactants. Dextrose is used also as a weak reducing agent in the dyestuff industry. Dextrose provides a highly assailable form of energy; it is a soluble carrier for special substance which requires to be diluted into the drinking water. Market Survey The demand for dextrin and dextrose is highly influenced by the growth of the manufacturing sectors mainly textiles, glass, printing ink food soft drink tanning tobacco and the like. The manufacturing sector has been growing by more than 6% in the past few years. Assuming the past trend will continue in the future, an annual average growth rate of 6% is applied to forecast the future demand by taking the current effective demand as a base. Starch and its derivatives have emerged as the most promising environment friendly ingredient over the years and offers varied application benefits in both food as well as non-food industries. There has been a steady increase in demand of starch in food & beverage industry due to high prices of sugar. Now, as Pharmaceutical industry is having a soaring business, so will be the dextrose business. Dextrose is used as energy providing ingredient to sick people. So the industries related producing dextrose will have a huge profitable business. Present Manufacturers Gujarat Ambuja Proteins Ltd. Indian Maize & Chemicals Ltd. K G Gluco Biols Ltd. [Merged] Kamala Sugar Mills Ltd. Origin Agrostar Ltd. Tirupati Starch & Chemicals Ltd. Unique Sugars Ltd. Wockhardt Health Care Ltd.
Plant capacity: 30 MT/ dayPlant & machinery: Rs.1336 Lakhs
Working capital: -T.C.I: Rs. 2429 Lakhs
Return: 35.00%Break even: 44.00%
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Invert Sugar - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Invert sugar is a mixture of glucose and fructose obtained by the hydrolysis of sucrose. Cane sugar comes from sugarcane which is the refined grain of sugar. Invert sugar is a liquid carbohydrate sweetener in which all or a portion of the sucrose present has been inverted. The sucrose molecule is split and converted to a mixture of glucose and fructose. Invert sugars help baked goods retain moisture and prolong shelf-life. Candy manufacturers use invert sugar to control graining. The resulting mixture of fructose and glucose is called inverted sugar syrup. Related to invertases are sucrases. Invertases and sucrases hydrolyze sucrose to give the same mixture of glucose and fructose. Invertases cleave the O-C (fructose) bond, whereas the sucrases cleave the O-C (glucose) bond. For industrial use, invertase is usually derived from yeast. Enzymatic treatment are now a major way of producing sweeteners, including syrups derived from sucrose or starch that contain mixture of glucose, maltose, fructose and other sugar. Glucose ahs 70-75% sweetening strength of beet sugar (sucrose) but fructose is twice as sweet as sucrose. Thus processes for the manufacture fructose are of considerable value, especially in the manufacture of candies and preserves, production of lactic acid and ethanol production from fermentation of cane sugar molasses. Invert sugar is 29-30% sweeter than the table sugar so the amount of sugar required for a particular degree of sweetness is also reduced enzymatic invert sugar does not involve the use of any chemical or acids unlike the conventional acid hydrolyzed invert sugar. Invert sugar is often incorporated in products where loss of water must be avoided. Commercially it is obtained from the inversion of a 96% cane sugar solution. Uses and Applications It can be used for carmellisation, enhancement of flavour and texture improvement. It improves the quality of the crust and makes the bread crumb softer. Yeast activation also becomes faster. When used for fruit processing, invert sugar increases the shelf life due to good humectants properties. It also enhances taste and flavor. It can be used for bee feeding and can be blended with honey. Chemically and physically it has the same properties as honey. As invert sugar restricts bacterial activity and is a chemically purer replacement of honey, it can be used in herbal cosmetics. Because of the glucose and fructose content, invert sugar provides instant energy and better taste. It is also popularly employed in the brewing Industry. The benefit of using invert sugar over regular sugar includes a better shelf life and more sweetness with lesser quantity when compared to the regular sugar. Besides bakery and honey making, Invert sugar is also used in Distillery and Pharma products. It is widely used in cough syrups for flavor enhancement. Market survey In the post-liberalisation era since the onset of the 1990s, the expanding demand for industrial products - of capital goods, intermediates and consumer durables and non-durables - has emerged as the most powerful stimulant to India's economic development and international capital inflows. The requirement for invert sugar syrup has been on the rise in India. The cost of pre-made invert sugar is significantly low because companies like Sai Sugar produce it in bulk. Overall invert sugar is widely produced in the state of UP and Uttrakhand in India because of high production of various grades of sugar and jaggery. The consumption of Invert Sugar is on the rise in India, and consumers demand quality products increasingly. By purchasing Invert sugar from the market, they are assured that the sugar syrup quality is uniformly maintained. Since Invert Sugar was commercially introduced India, it has seen a tremendous growth, especially in the last 2 years. Since India is expected to continue its growth trend in Confectionary and Pharma industry, the demand of Invert sugar is all set to rise. Companies like Bicardi, Parle and pretty much all confectionery and pharmaceutical companies use invert sugar today. Based on latest trends the usage of invert sugar is rising 50% every year and now penetrating in small bakery and Kirana shops too. The retail market is valued at Rs 9 tn, of which food, grocery and personal home products constitute Rs 6 tn. According to A.C. Neilson, 60% of the shopping needs are purchased at larger outlets for monthly baskets, but convenience stores command a 40% for daily top-up requirements'. Modern retail outlets constitute 5% of all sales. Honey makers widely mix about 20-30% of inverted syrup with honey to bring down the cost of product and keep up with the rising demand. Technically honey and invert sugar share a very close chemical structure. Few Indian Major Players are as under: Dhampure Specialty Sugars Ltd. Sangita Bio-Chem Ltd.
Plant capacity: 20.0 MT/ Day.Plant & machinery: Rs.285 Lakhs
Working capital: -T.C.I: Cost of Project:Rs.577 Lakhs.
Return: 40.00%Break even: 53.00%
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L-LYSINE FROM MICROBIAL FERMENTATION - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

L-Lysine is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. It is an essential amino acid for humans. Lysine's codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ?-amino group often participates in hydrogen bonding and as a general base in catalysis. (The ?-amino group (NH3+) is attached to the fifth carbon beginning from the ?-carbon, which is attached to the carboxyl (C=OOH) group. Common posttranslational modifications include methylation of the ?-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications at lysine residues include acetylation and ubiquitination. Collagen contains hydroxylysine, which is derived from lysine by lysyl hydroxylase. O-Glycosylation of hydroxylysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell. Lysine is one of the essential amino acids not synthesized biologically in the body. Children and growing animals have a high requirement of lysine, since it is needed for bone formation. Lysine is generally recognized as the most deficient amino acid in the food supply of both man and domestic meat producing animals. Since animal feed, such as grain and defatted oil seeds contain only small quantities of lysine, poultry, cattle and other live stocks are unable to synthesize this amino acid. So it must be added to these feed stuff to provide adequate diet. The excretion of small amount of alanine, glutamic acid, aspartic acid and histidine in a culture of E. coli. addition of ammonium salt in excess of that required for growth resulted in increased amino acid production. The principles of the fermentative method quickly gained acceptance, and systematic work soon began on the production of other amino acids. This marked the birth of the amino acid fermentation industry.The possible utilization of wild strain revealed that many microorganisms, such as bacteria, yeast, filamentous fungi and action mycetes, accumulated amino acids in culture containing a supplementary source of nitrogen. The biosynthetic pathways of most amino acids are now well moved to metabolic control and its break down, including the genus and species specificity of the phenomenon. Protein production by microorganisms rich in essential amino acids are source both as a food supplement and as a source of amino acid. Fifteen amino acids were found in cell hydrolyzate, of which arginine and L-lysine is the most abundant. Most natural strains cannot produce industrially significant amounts of L-lysine in the culture broth due to various metabolic regulation mechanisms. Alteration of these mechanism can lead to L-lysine accumulation. USES & APPLICATION Lysine production for animal feed is a major global industry, reached in 2009 almost 700,000 tonnes for a market value of over €1.22 billion. Lysine is an important additive to animal feed because it is a limiting amino acid when optimizing the growth of certain animals such as pigs and chickens for the production of meat. Lysine supplementation allows for the use of lower-cost plant protein (maize, for instance, rather than soy) while maintaining high growth rates, and limiting the pollution from nitrogen excretion. In turn, however, phosphate pollution is a major environmental cost when corn is used as feed for poultry and swine. Lysine is industrially produced by microbial fermentation, from a base mainly of sugar. Genetic engineering research is actively pursuing bacterial strains to improve the efficiency of production and allow lysine to be made from other substrates. The requirements of amino acids in animals are well defined in various sets of recommendations such as those of NRC (National Research Council), USA, etc. Requirements vary depending on the species and age of animals. Amino acids should be supplied either in the form of protein or crystalline amino acids in feed to meet requirements. By comparing requirements and the actual amino acids present in feed, the order of ‘limiting amino acids’ can be estimated. The orders of limiting amino acids in pig and broiler feeds, composed of corn (or wheat) and soybean meal. Crystalline amino acids should be added to feed in the order of limiting amino acids when the protein content of the feed is reduced, which is the reason why DL-Methionine and L-Lysine HCl were initially introduced to feed. Now, with a more economic supply of L-Threonine and L-Tryptophan available, use of amino acids has entered a new era, in which the use of second and third limiting amino acids is taking off. For example, in the past two to three years, the annual growth rate of L-Threonine usage has been above 20 percent. Since the protein level required by livestock is reduced further with the introduction of second and third limiting amino acids, use of the first limiting amino acid will also be expanded. MARKET SURVEY It can be said that the use of L-Lysine in animal feed in India is largely in the introductory stage at present. The demand is bound to go up, in view of the compulsive need to optimise the quality of the animal feed by the producers to stay ahead in the competitive market. The Indian demand for L-Lysine is estimated to be around 1000 tonnes per annum. Estimated growth rate in demand: 9 to 10% per annum. The global demand for L-Lysine Hydrochloride is around 5,00,000 tonnes per annum with the projected growth rate in demand of around 8.0%. Considering the fact that around 25,000 tonnes of additional capacity has to be created for L-Lysine Mono-hydrochloride to meet the global demand every year, it should be possible for the Indian project to take substantial share in the export market. This would be so, in view of the fact that the Molasses based L-Lysine project in India would be globally competitive from the point of view of the cost factors. The important aspects of the L-Lysine is that the product is based on cane molasses, which is adequately available in the country.
Plant capacity: 17 MT/DayPlant & machinery: Rs 328 Lakhs
Working capital: -T.C.I: Cost of Project: Rs 910 Lakhs
Return: 24.64%Break even: 52.18%
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FRUCTOSE SYRUP FROM BROKEN RICE (HFS 90%)- Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

Glucose syrup is a popular substitute for sugar. It is more commonly referred to as corn syrup because its main ingredient is usually cornstarch. From a strictly chemical perspective, glucose syrup is the proper term for any liquid starch consisting of carbohydrates. In addition to cornstarch, it can be made from any form of starch, including wheat, rice or potatoes. Because of its successful and easy bonding with dry or solid substances, this syrup is the preferred sweetener for candy, chewing gum, jams, jellies and canned fruit. The main benefit of this syrup over regular granulated sugar is its non-crystallizing properties. It is also praised for its preservative qualities. Makers of chocolate, ice cream and bakery products also prefer this syrup to sugar. Ice cream makers appreciate the anti-melting feature it adds to the frozen treat. Cream and fruit fillings in bakery products get a lot of their fluffiness and bulk from this type of syrup. Non-sweet foods and drinks also benefit from glucose syrup. The syrup also aids in fermentation and brewing processes utilized in beer and alcohol production. The high carbohydrate content preferred in processed baby foods is provided by the addition of this sugar substitute as well. Products not normally associated with sugar or sweeteners, such as pharmaceuticals, also contain this versatile syrup. It is used to flavor cough syrups and to make the coatings on vitamin and medicine tablets. Chewing tobacco is flavored with glucose syrup as well, which makes it appealing to the palate. The tobacco used in cigarette production is treated with this syrup solution to smooth out the taste of the tobacco. Both products also remain fresher longer due to the addition of this sweet additive. Non-consumables, such as leather, benefit from glucose syrup used in the tanning process. Dipping leather in glucose syrup gives it an appealing, glossy shine and makes the grain look fine. The syrup also makes the leather more pliable. When incorporated into oil extraction procedures, glucose syrup aids in the thickening process and adds gumming properties. Along those same lines, it stabilizes glues and adhesives and aids in keeping concrete from hardening too quickly. High fructose syrup is one kind of colorless or light yellow, transparent ropy liquid. It is gentle and sweet with special odour of fructose with neither any abnormal taste nor impurities. It has two types: one is 42%, the other is 55%. Fructose is processed from hydrolyzed rice starch and contains fructose a simple sugar carbohydrate, just like sucrose. It is about 95% sweeter than sucrose, less expensive than sugar, and mixed well in many foods. The content of fructose is more than 42% of total carbohydrates. USES & APPLICATION For human health, it can stimulate the metabolism of blood alcohol, which is helpful to prevent the damage caused by the excessive blood alcohol. A patient with 500ml fructose (40%) injection mainlined will gain good recovery. Fructose is one of natural carbohydrates that consist in fruits as well as in honey. With high sweet it can substitute for sucrose, which has some advantages: Fructose, also called "fruit sugar", is another important hexose found in many fruits and vegetables. Fructose satisfies the "sweet tooth", tasting twice as sweet as sucrose so it can be used in lower amounts. With good sweet sense and taste it is favorable for the use in carbonated drinks, beverages. It has already be used in some big drinks such as Coca Cola. Pepsi-Cola etc. It can improve textures and enhance colors without masking natural flavors, as in canned fruits and vegetables. So, it has already been a king of good sweetener in the beverage industry. It maintains moisture so cakes or breads keep soft, fresh without going stale and longer shelf life. It can depress freezing to prevent crystal formation in ice cream and other frozen desserts and keep products soft and delicious. Fructose is widely used in beverages, carbonated drinks, fruit drinks, breads, cakes, tinned fruits, jams, succades, dairy foods etc. MARKET SURVEY Indian tops the list sugar producing countries. The status of sugar industries in India, indicates that the existing sugar mills are a typical mix of old and new plants. Per capita consumption of sugar and other products like Gur and Khandsari is going up and is expected to increase from 12.3 and 12.5 kg to 17.0 kg and 16.0 kg respectively by the end of this century. Studies on the raw material situation for the last 13 years reveal, that cane production has stagnated at about 60 tons per hectare with less than 1% increase per year from 1977-78 to 1989-90. Any scope of enhanced production of sugar-cane must come mainly from the development of high yielding varieties and improved farm practices. The limitation of traditional sources for meeting the ever increasing demand of sweeteners must be recognized. Therefore, manufacture of sweeteners based on starchy materials offers an attractive source to fill up the demand-supply gap of sugar as suggested by experts. The Indian scene of HFCS industry is at a nascent stage. One or two units engaged in this field are either in the establishment stage or had stopped producing HFCS due its high cost of production and poor demand in the consumer sector. The production and consumption of this particular product is not only limited due to its high cost, but also due to a general non-awareness about HFCS in the society. So, promotion of HFCS industry also demands an intensive campaign, highlighting the important advantages of HFCS, especially its rapid metabolism process in the human body and independence of insulin. The know-how for the manufacture of maize starch and its subsequent conversion to liquid glucose, meltodextrines, dextrose and sorbitol is indigenously available. HFCS is finding an increased use in soft drinks manufactured in the advanced countries. 50% to complete replacement of sugar with HFCS has been permitted in the U.S.A. Soft drink manufacturers in the country may also be persuaded to opt initially for at least 15-20% replacement. Gradually, other industries like bakery, processed foods, ice-creams etc., should also consider sugar replacement by HFCS.
Plant capacity: 30 MT/DayPlant & machinery: Rs. 343 Lakhs
Working capital: -T.C.I: Cost of Project: Rs. 1525 Lakhs
Return: 24.28%Break even: 55.59%
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