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Active Pharmaceutical Ingredient (API) Products, Bulk API Manufacturing

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Ciprofloxacin - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Drug and pharmaceutical industry is one of the basis industries of India. Recent moves in globalization and liberalization has affected this industry perhaps the highest. Pharmaceutical industry has close linkages with imports of material and technology of process know how and therefore with international economic. The industry started with manufacture of formulation from imported drugs in early 1940s. After independence with a view to ensure availability of good quality drugs at reasonable prices. Ciprofloxacin is used as anti bacterial drug or some time it is used as antibiotics. It is manufactured in India by few organized sectors as well as many private companies are engaged in the production of this product. There is very good indigenous demand as well as there is good export demand is available. So it can be concluded that any new entrepreneur may enter in this field with success.
Plant capacity: 300 Kgs./DayPlant & machinery: Rs. 44.0 Lakhs
Working capital: Rs. 130.0 LakhsT.C.I: Rs. 231.0 Lakhs
Return: 66.49%Break even: 35.01%
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Paracetamol - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Paracetemol is an important intermediate in the manufacture of other pharmaceuticals like the antimalarial amodiaquine. Two types of paracetamol are commercially produced, namely powder and granules. The granules grade is called direct compressible product which is easier to use for making tablets. Three of the major manufacturers are in Andhra Pradesh? Srikrishna Pharma, Triton Laboratories and Srinivasa Agro industries and drug. The annual domestic requirement of paracetamol powder is about 10,000 tonnes. The total production is put at about 13,000 tonnes with the balance being exported. Paracetamol bulk drug project is considered as an ideal investment opportunity in small scale sector. There is good scope for new investment.
Plant capacity: 10 Tonnes/DayPlant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: 1.00%
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Ciprofloxacin - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Drug and pharmaceutical industry is one of the basis industries of India. Recent moves in globalization and liberalization has affected this industry perhaps the highest. Pharmaceutical industry has close linkages with imports of material and technology of process know-how and therefore with international economic. The industry started with manufacture of formulation from imported drugs in early 1940s. After independence with a view to ensure availability of good quality drugs at reasonable prices. Ciprofloxacin is used as anti bacterial drug or some time it is used as antibiotics. It is manufactured in India by few organized sectors as well as many private companies are engaged in the production of this product. There is very good indigenous demand as well as there is good export demand is available. So it can be concluded that any new entrepreneur may enter in this field with success.
Plant capacity: 300 Kgs./DayPlant & machinery: Rs. 44.00 Lakhs
Working capital: Rs. 130.00 LakhsT.C.I: Rs. 231.00 Lakhs
Return: 66.49%Break even: 35.01%
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Ciprofloxacin - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics

Drug and pharmaceutical industry is one of the basis industries of India. Recent moves in globalization and liberalization has affected this industry perhaps the highest. Pharmaceutical industry has close linkages with imports of material and technology of process know-how and therefore with international economic. The industry started with manufacture of formulation from imported drugs in early 1940s. After independence with a view to ensure availability of good quality drugs at reasonable prices. Ciprofloxacin is used as anti bacterial drug or some time it is used as antibiotics. It is manufactured in India by few organized sectors as well as many private companies are engaged in the production of this product. There is very good indigenous demand as well as there is good export demand is available. So it can be concluded that any new entrepreneur may enter in this field with success.
Plant capacity: 300 Kgs./DayPlant & machinery: Rs. 44.0 Lakhs
Working capital: Rs. 130.0 LakhsT.C.I: Rs. 231.0 Lakhs
Return: 66.49%Break even: 35.01%
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Paracetamol Used Phenol As Building Block - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

Block using purification of Para – Aminophenol (pap) antipyretic analgesic or febrifuges are remedial agents that lower the temperature of body in pyrexia i.e., in situations when the body temperature has been raised above normal. In therapeutic dose they do not have any effect on normal body temperature. These antipyretic agents also have mild analgesic activity. Amongst the most common group of compounds used as antipyretic analgesics are Salicylates, aniline and Aminophenol analogue, Purazolones and Quinoline derivatives. Though these Helerogenous groups of compounds are analgesics. They have Noddiclive properties. Their analgesics use is limited to mild aches and pains like headache and backache. India opted for a manufacturing process patent regime that was carefully designed to make drugs available at lower prices to consumers. The policy led to a sound base for drug manufacturing in the country. Of course, it hindered innovation and research-based drug development. The situation has changed with the emergence of innovative cures for various ailments. Per capita spending on pharmaceuticals around the world increased from $ 72 in 2000 to $ 90 in 2005. So new entrepreneur enter in this business will be successful.
Plant capacity: 5 Mt/DayPlant & machinery: US $ 376 Lakh
Working capital: N/AT.C.I: US $ 18.75 Lakh
Return: 39.00%Break even: 53.00%
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7 AMINOCEPHALOSPORANIC ACID (7 ACA) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

7 ACA or 7 Aminocephalosporanic acid is made from Cephalosporin C and is a key intermediate for synthesizing cephalosporin antibiotics, the B lactam antibiotics family. 7 ACA is a starting compound for the production of various semi-synthetic cephalosporins of different generations. These compounds are made by modification of the side chains at positions 3 and 7 of 7-aminocephalosporanic acid (7 ACA). It is used to produce many cepholosporins pharmaceutical bulks, such as cefazolin sodium, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, ceftazime sodium, cefuroxime sodium and so on. Originally, the commercial processes were based on solvent extraction. 7 Aminocephalosporanic acid (7 ACA), until recently it has been produced by chemical deacylation of the natural antibiotic cephalosporin C. The disadvantage of this method is multiple steps, low yield, use of various organic solvents and treatment of a lot of toxic waste. Alternatively, 7 ACA can be produced by a simpler and more environmentally sound process using a bio-catalytic method based on DAAO and glutaryl hydrolase for enzymatic deacylation of CPC to 7 ACA. However, few enzymes capable of this direct deacylation have been discovered, probably because of the unusual nature of the D aminoadipyl side chain of cephalosporin C. Enzyme engineering is a fast growing application in the pharmaceutical market. Cephalosporin is defined as any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and is related to the penicillins in both structure and mode of action but relatively penicillinase resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. The cephalosporins belong to the family of ? lactam antibiotics. These are named after the reactive moiety of the compounds, the ? lactam ring. In CPC, the four membered ? lactam ring is coupled to a six membered dihydrothiazine ring to form the nucleus, 7 aminocephalosporanic acid (7 ACA), and a side chain, ? aminoadipic acid, is coupled via an amide bond to the nucleus. The total world market for cephalosporins was estimated to be approximately 10 billion US$ in 2000, and ? lactam antibiotics in general accounting for over 65% of the world antibiotic market. According to IMS Health, cephalosporins as single preparation and in combination preparations are ranked 10 in the global drug sales in 2003 by an estimated sales of 8.3 billion US$, the highest ranking for any of the anti infectives classes. The size of the Indian pharmaceutical industry is poised to treble over the decade. It is expected to grow from about USD 6.3 billion in 2005 to about USD 20 billion by 2015, registering a CAGR of 12.3% and outperforming the global average of 9% in 2009 to 10. In terms of scale, the Indian pharmaceutical market is the 14th largest in the world but will graduate to the top 10 by 2015, overtaking Brazil, Mexico, South Korea and Turkey. India’s growth to a USD 20 billion market by 2015 indicates that the incremental growth of USD 14 billion over the coming decade is likely to be the third highest in the world. Demand for 7 ACA is principally determined by the market sales scale of downstream products. In terms of developing trend, ceftriaxone and cefazolin were two mainstream products of 7 ACA. Therefore, the market change in these two products directly affected the change in production-sales relations of 7 ACA. After dosage conversion, according to estimate the use of 7 ACA for making certriaxone accounted for 47.7% of the total consumption of 7 ACA. Obviously, ceftriaxone had become the biggest consumer of cephalosporins raw materials of 7 ACA series, followed by cefazolin. Not only ceftriaxone boosted morale, but cefotaxime, cefazolin sodium, cefoperazone sodium, cefoperazone sulbactam, ceftazidime, cefuroxime, etc were also the direct contributors of the family. At present, major players in the market include Shijiazhuang Pharmaceutical Group Co. Ltd., Fujian Fukang Pharmaceutical Group Co. Ltd., Shanxi Weiqida Pharmaceutical Group Co. Ltd. and Zhuhai United Labs Co. Ltd. At present there is no production of 7 ACA in the country and the demand is met by imports. There is a good scope for capacity creation in India. New entrepreneurs should venture into this sector.
Plant capacity: 150 MT/AnnumPlant & machinery: 1486 Lakhs
Working capital: -T.C.I: Cost of Project : 2167 Lakhs
Return: 64.00%Break even: 42.00%
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Ciprofloxacin HCl –Cipro - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

PRODUCT PROFILE Ciprofloxacin belongs to a class of drugs called quinolone antibiotics. It is a second generation fluoroquinolone antibacterial. It works by stopping the growth of bacteria and kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops synthesis of DNA and of protein. Ciprofloxacin interacts with other drugs, herbal and natural supplements, and thyroid medications. Ciprofloxacin was first patented in 1983 by Bayer A.G. and subsequently approved by the U.S. Food and Drug Administration (FDA) in 1987. Ciprofloxacin hydrochloride, USP, a fluoroquinolone, is the monohydrochloride monohydrate salt of 1 cyclopropyl 6 fluoro 1, 4 dihydro 4 oxo 7 (1 piperazinyl) 3 quinolinecarboxylic acid. Ciprofloxacin inhibits an enzyme called DNA gyrase that is an essential component of the mechanism that passes genetic information onto daighter cells when a cell divides. Product characteristics Trade names - Ciloxan, Cipro Mol. Formula. - C17H18FN3O3HCl.H2O Molecular weight - 385.8 Appearance - Powder; does not mix well with water. Description - Antibiotic Shelf life - Good Bioavailability - 69% State - Solid, Divided solid Applications Ciprofloxacin is used to treat a number of infections including: infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, chancroid, among others. Ciprofloxacin is available as tablets, intravenous solutions, eye and ear drops. It can also be used to treat some sexually transmitted infections (STIs), some forms of infectious diarrhea, and typhoid fever. The extended release form of ciprofloxacin is used to treat bladder and kidney infections. Global demand • India accounts for less than two per cent of the world market for pharmaceuticals, with an estimated market value of US$10.4 billion in 2007 at consumer prices, or around US$9 per capita. • Espicom's market projections put the market at US$15.6 billion by 2012 by assuming a modest but sustainable market growth of around 8.4% per year. • However, McKinsey has predicted that just the Indian domestic market alone is expected to grow from US$6.3 billion in 2005 to about US$20 billion by 2015. • The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. The demand of Ciprofloxacin in the market is immense and therefore its market position is splendid. Hence it is an excellent field to venture.
Plant capacity: 180 MT/ AnnumPlant & machinery: 225 Lakhs
Working capital: -T.C.I: Cost of project: 549 Lakhs
Return: 43.00%Break even: 59.00%
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Active Pharma Ingredients(API) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue

An active ingredient (AI) is the substance in a pharmaceutical drug or a pesticide that is biologically active. The similar terms active pharmaceutical ingredient (API) and bulk active are also used in medicine, and the term active substance may be used for pesticide formulations. Some medications and pesticide products may contain more than one active ingredient. A dosage form: the API, which is the drug itself; and an excipient, which is the substance of the tablet, or the liquid the API is suspended in, or other material that is pharmaceutically inert. Drugs are chosen primarily for their active ingredients. The Indian pharmaceutical industry also needs to take advantage of the recent advances in biotechnology and information technology. The future of the industry will be determined by how well it markets its products to several regions and distributes risks, its forward and backward integration capabilities, its R&D, its consolidation through mergers and acquisitions, co-marketing and licensing agreements. Uses and Applications API like Cephalexin is used to treat a number of infections including: otitis media, streptococcal pharyngitis, bone and joint infections, pneumonia, cellulitis, and urinary tract infections. It may be used to prevent bacterial endocarditis. Amoxicillin is used in the treatment of a number of infections, including acute otitis media, Streptococcal pharyngitis, pneumonia, skin infections, urinary-tract infections, Salmonella, lyme disease, and chlamydia infections. It is also used to prevent bacterial endocarditis in high-risk people who are having dental work done, to prevent strep pneumococus infections in those without spleens, and for both the prevention and the treatment of anthrax. Ibuprofen is used primarily for fever, pain, dysmenorrhea and inflammatory diseases such asrheumatoid arthritis. It is also used for pericarditis and patent ductus arteriosus. Market Survey The demand for pharmaceutical products in India is significant and is driven by low drug penetration, rising middle-class & disposable income, increased government & private spending on healthcare infrastructure, increasing medical insurance penetration etc. India based pharmaceutical companies are not only catering to the domestic market and fulfilling the country’s demands, they are also exporting to around 220 countries. They are exporting high quality, low cost drugs to countries such as the US, Kenya, Malaysia, Nigeria, Russia, Singapore, South Africa, Ukraine, Vietnam, and more. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. Few Major Players are as under:- Cipla Ranbaxy Lab Dr Reddy's Labs Sun Pharma Lupin Ltd Aurobindo Pharma Piramal Health Cadila Health Matrix Labs Wockhardt
Plant capacity: Cephalexin Monohydrate: 500 Kgs/Day, Ampicillin Trihydrate: 500 Kgs/Day,Ibuprofen: 500 Kgs/DayPlant & machinery: Rs.448 Lakhs
Working capital: -T.C.I: Cost Of Project : Rs.958 Lakhs
Return: 46.00%Break even: 44.00%
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Production of Paracetamol (Acetaminophen) Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain. The quality of the evidence regarding the use for fever relief in children is poor. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hours. Paracetamol lacks anti-inflammatory action in rheumatic disorders. However, it is less toxic than the Aspirin and does not produce anemia and liver damage, which sometimes result from the continued use of acetanilide and acetophenotidine. It is also an important intermediate in the manufacture of other pharmaceuticals like the antimalarial amodiaquine. Few Indian Major Players are as under: • Alta Laboratories Ltd. • Granules India Ltd. • HaffkineAjintha Pharmaceuticals Ltd. • Pan Drugs Ltd. Market Outlook The pharmaceutical industry in India ranks 3rd in the world terms of volume and 14th in terms of value. 20% of global exports in generics, making it the largest provider of generic medicines globally. USD 45 Billion in revenue by 2020, revenue of USD 55 billion by 2020 as base case, and can grow to USD 70 billion in an aggressive case scenario. USD 26.1 Billion in generics by 2016. USD 200 Billion to be spent on infrastructure by 2024. Global acetaminophen market was valued at around USD 801.3 million in 2014 and is expected to reach USD 999.4 million in 2020, growing at a CAGR of around 3.8% between 2015 and 2020. In terms of volume, the global acetaminophen market stood at above 149.3 kilo tons in 2014. The global paracetamol market is expected to reach US$1,049.7 mn by 2022 as compared to its valuation of US$900.2 mn in 2014. Tags Paracetamol Manufacturing Plant, Paracetamol Production, Paracetamol Manufacturing, Paracetamol Manufacturing Process, Production of Paracetamol, Paracetamol Production Process, Manufacturing of Paracetamol Tablets, Paracetamol Manufacture in India, Manufacture of Paracetamol, Paracetamol Manufacturing Unit, Pharmaceutical Industry, Production Plant of Paracetamol, Pharmaceutical Manufacturing Business, Production Process of Paracetamol, Acetaminophen Manufacture, Manufacturing Plants of Paracetamol, Acetaminophen Manufacturing Plants, Industrial Production of Paracetamol, Business Plan for Acetaminophen Manufacturing, Paracetamol Manufacturing Business, Paracetamol Manufacturing Industry, Production of Acetaminophen Production Plant of Paracetamol, How to Prepare Paracetamol, Manufacturing and Formulation of Paracetamol, Paracetamol Manufacturing Project Report, Method for Manufacturing of Paracetamol, Method for Production of Paracetamol, Paracetamol Production Method, Manufacturing Method of Paracetamol, Production Plan for Paracetamol, Manufacturing Business of Paracetamol, Business Ideas for Manufacturing of Paracetamol, Small Scale Paracetamol Manufacturing Business Ideas & Opportunities, Process for Producing Paracetamol, Preparation Method for Paracetamol, Profitable Paracetamol Manufacturing Business, Start Production of Paracetamol, Paracetamol Manufacturing Process in India, How to Make Paracetamol, Method of Making Paracetamol, Drugs Manufacturing Project, Drugs Manufacturing Plant, Drugs Production, Paracetamol Manufacturing Project Ideas, Projects on Small Scale Industries, Small Scale Industries Projects Ideas, Paracetamol Manufacturing Based Small Scale Industries Projects, Project Profile on Small Scale Industries, How to Start Acetaminophen Manufacturing Industry in India, Paracetamol Manufacturing Projects, New Project Profile on Paracetamol Manufacturing Industries, Project Report on Acetaminophen Manufacturing Industry, Detailed Project Report on Paracetamol Production, Project Report on Paracetamol Manufacturing, Pre-Investment Feasibility Study on Paracetamol Manufacturing, Techno-Economic Feasibility Study on Paracetamol Manufacturing, Feasibility Report on Paracetamol Manufacturing, Free Project Profile on Paracetamol Production, Project Profile on Acetaminophen Manufacturing, Download Free Project Profile on Paracetamol Production, Industrial Project Report, Project Consultant, Project Consultancy, NPCS, Niir, Process Technology Books, Business Consultancy, Business Consultant, Project Identification and Selection, Preparation of Project Profiles, Startup, Business Guidance, Business Guidance to Clients, Startup Project for Paracetamol Manufacturing, Startup Project, Startup Ideas, Project for Startups, Startup Project Plan, Business Start-Up, Business Plan for Startup Business, Great Opportunity for Startup, Small Start-Up Business Project, Project Report for Bank Loan, Project Report for Bank Finance, Project Report Format for Bank Loan in Excel, Excel Format of Project Report and CMA Data, Project Report Bank Loan Excel, Detailed Project Plan Reports
Plant capacity: Paracetamol Tablets: 1500mt/annum Paracetamol Powder: 420mt/annumPlant & machinery: 349 Lakhs
Working capital: -T.C.I: 863 Lakhs
Return: 27.00%Break even: 46.00%
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Acyclovir

Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection. It can be taken by mouth, applied as a cream, or injected. Acyclovir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Acyclovir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. Acyclovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, inject able, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). The acyclovir market is segmented on the basis of types of herpes virus, mechanism of action, application, and region. On the basis of types of virus they are segmented into herpes simplex virus type I (HSV-1), herpes simplex virus type II (HSV-2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Based on mechanism of action, the market is segmented into nucleotide polymerase inhibitors, reverse transcriptase inhibitors, protease inhibitors, and others.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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