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Pharmaceutical, Drugs, Fine Chemicals, Bulk Drug Intermediates, Pharmaceutical Drugs, Pharma Drug Ingredients Intermediates, Drug Intermediates, Speciality Chemicals, Raw Materials, Fine and Specialty Chemicals Intermediates, Pharmaceutical Bulk Drugs

Indian drugs and pharmaceutical industry has advanced perceptibly and is getting ready  for the new patent regime and  to withstand global competition, which is expected to be unleashed by new winds of liberalisation - a new era of liberalisation - much different from what was ushered in since the conclusion of the Uruguay Round and the establishment of the World Trade Organisation.

The industry has been expanding at annual rates ranging between 8 to 10% (against global growth rate of 6%).  According to a study  by McKinsey, Vision 2010, the domestic pharmaceutical industry could attain a size of  $25 billion (Rs 1200 billion) by 2010 by focusing on two areas: first, innovation-led research, development and new drug discoveries; and second, information technology-led remote sales and marketing.  The market for bulk drugs and formulations had increased from about Rs 103  billion in 1990-91 to an estimated Rs 435  billion at the end of 2003-04.  The prices of Indian essential drugs are among the lowest in the world. Apart from strides made by the industry in the last half-a-century, lower production cost due to reverse engineering and low R&D outlays has been a major factor in keeping the prices under check.

The global pharmaceutical industry is estimated at $ 300 billion, not all representing cross-border trade.  India's measly share of $ 1.5 billion in global trade represents an untapped potential. Under the regime of economic liberalisation underway since early 1990s, the drugs and pharmaceutical sector witnessed initiatives at fresh investment in the sector. Nearly 1735 investment proposals of the order of around Rs 166  billion were initiated. The foreign collaboration proposals approved numbered around 425 with a foreign direct investment  (FDI) component of over Rs 25 billion. The pharmaceuticals have figured high on the export front. In 2001-02,  the sector was  estimated to have registered a growth of 17.6% at around Rs 20.3 billion.

In the wake of economic liberalisation, many a  overseas players  returned or contemplated returning to India. These include Ivox Corp (USA),  Taro Pharmaceuticals (Israel) and Merck (USA). These are out either to set shop or looking for acquisitions in India. Hexal AG of Germany has established a liaison office in India. MILLIONCs like Rocha, Bayer, Aventis and Chiron are making India a regional hub for bulk drugs. 

The Export Import Bank of India (Exim Bank) had  doubled its corpus for the pharmaceutical industry to Rs 2 billion as a result of increased activity in the industry, especially in the external sector. The fund is used for the development and commercialisation of the new products and applications, significant improvement in the existing design of  products, setting up and expansion of pilot plants, research studies for obtaining regulatory approvals, cost of filing and managing international patent and R&D Centres.

It needs, however, to be recognised that the presence  of small scale manufacturers has resulted, on the one hand,  in a highly fragmented industry, and on the other, it has made it possible to supply a near 100,000 drugs including vitamins, antibiotics, antibacterials, cardio-vascular and other essential drugs. These account for nearly 37% of the market.  While each of about 80% of the manufacturers has annual sales below a billion rupees, top ten companies are known to control over 30% of the market. At present there are more than 20,000 players in the country.

The major players are: Alembic Chem, Aurobindo Pharma, Cipla, Dr. Reddy's, FDC, IPCA Labs, Jagsonpal Pharma, J.B. Chemicals, Kopran, Lupin Labs, Lyka Labs, Morepan Labs, Nicholas Piramal, Ranbaxy Labs, Sun Pharma, Themis Medicare, GlaxoSmithkline, Astrazeneca, Aventis, E-Merck, Torrent Pharma, TTK Healthcare, Unichem Labs,  Wockhardt  and  Zandu Pharma.  Until recently, only a few of the Indian companies had gone into any serious R&D activity. Much of the effort was directed to affordable analogue research. The R&D level in the country is low with even well-placed pharma companies spending less than 2% of turnover on R&D. MILLIONCs are known to contribute as much as 10% or more of their turnover to R&D.  While India is very strong in process chemistry, biology and applied bio-chemistry, initiatives at all levels - government, academia, private sector - involving heavy financial outlays, are called for.

Ayurveda continues to remain a preferred system of medicine for a vast segment of population in the country. The country has over 400,000 registered practitioners of the Indian system of medicine. Around 170 institutes properly affiliated to various universities impart under- or post-graduate courses each year. These institutes churn out some 5,500 fresh practitioners. The practitioners are supported by 12,000 dispensaries and 2,100 beds available for ayurveda treatment countrywide. The emerging biotechnology sector has already taken by storm and is offering sops to states to make these as the thriving ground for the highly potential segment in medicare.

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I.V. Fluids

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenousadministration. I.V. fluids or Intravenous fluids are life saving drugs, which are widely used in surgery, pediatrics, urology, obstetrics and gynecology. They are given mostly to patients suffering from dehydration, diarrhoea, vomiting, gastroenteritis and excessive perspiration. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. Thus, due to demand it is a good project for entrepreneurs to invest. Few Indian Major Players are as under • AxaParenterals Ltd. • D.J. Laboratories Pvt. Ltd. • Baxter International Inc. • Amanta Healthcare • Aishwarya Healthcare
Plant capacity: I.V. Fluid (500 ml.):14,400,000 Bottles/annumPlant & machinery: Rs 476 lakhs
Working capital: -T.C.I: Cost of Project: Rs 1092 lakhs
Return: 26.00%Break even: 53.00%
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Surgical Cotton

Cotton is a soft, staple fiber that grows in a form known as a boll around the seeds of the cotton plant, as shrub native to tropical and subtropical regions around the world, including the Americas, India and Africa. Surgical cotton is also known as absorbent cotton” or “cotton wool”. Surgical/Absorbent cotton is cleared de-oiled and bleached cotton packed in different sizes. The fiber of Surgical/Absorbent cotton is very elastic. It consists of 98%-99.5% of cellulose which has a diameter of 16.30 and a length of 12-40 mm. Today, India produces the widest range of cotton; perhaps no other cotton producing country in the world has this distinction. The demand of Surgical Absorbent Cotton is directly related with the increase in population and expansion of public health services. Government hospitals and large nursing homes are the largest consumer for cotton wool. the area under surgical cotton cultivation in India was 97 percent in 1947, it fell to 42 percent in 1990, 28 percent in 2000 and about 1 percent in 2012, and it is now estimated to be much less than 1 percent. Meditech in India is expected to grow at a CAGR of 9.1% from US$ 600 million in 2014 to US$780 million in 2017. As a whole any entrepreneur can venture in this project without risk and earn profit. Few Indian major players are as under • Jajoo Surgicals Pvt. Ltd. • Mohini Fibers Limited • Pradeep Surgical Dressings Pvt. Ltd. • Medicare Healthcare Product • Bafna Healthcare Pvt. Ltd. • BVM Meditech Private Limited
Plant capacity: 1300 Kgs/day Plant & machinery: 191 lakhs
Working capital: -T.C.I: Cost of Project: Rs 278 lakhs
Return: 26.00%Break even: 64.00%
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Dental Materials (Alginate, GI Cement, Composite Resin & Polycarboxylate Cement)

A dental impression is a negative imprint of hard (teeth) and soft tissues in the mouth from which a positive reproduction (cast or model) can be formed. Impression material is of liquid or semi-solid nature when first mixed and placed in the mouth. It then sets to become an elastic solid (usually takes a few minutes depending upon the material), leaving an imprint of person's dentition and surrounding structures of oral cavity. Alginate is an irreversible hydrocolloid. It exists in two phases: either as a viscous liquid, or a solid gel, the transition generated by a chemical reaction. The overall setting double composition reaction is as follows: Potassium (sodium) alginate + calcium sulphate dihydrate + water ? calcium alginate + potassium (sodium) sulphate Sodium phosphate is added as a retarder which preferentially reacts with calcium ions to delay the set of the material. The market has been estimated at USD 6.2 billion in 2016 and is projected to reach USD 8.5 billion by 2021, at a CAGR of 6.5% during the forecast period from 2016 to 2021. Dental equipment is tools used to diagnose and treat dental diseases. Dental tools are used by dental professionals to examine, manipulate, restore and remove teeth and surrounding oral structures and to provide dental treatment. The end-users for this market include hospitals, dental clinics, and dental practitioners. The Global Restorative Dentistry Market is projected to Reach USD 21.27 Billion by 2022 from USD 15.60 Billion in 2017, at a CAGR of 6.4% Increase in the prevalence of dental diseases (dental caries and edentulism), rising demand for advanced cosmetic dental procedures, growing dental tourism, and increasing dental expenditure are the major factors driving the demand for restorative dentistry. As a whole any entrepreneur can venture in this project without risk and earn profit.
Plant capacity: Composite Resin Poly Carboxylate Cement (500 gms Pack): 80 Packs/ Day Glass Ionomer Cement (15 gms Packs with 10 gm Liquid): 1333 Packs/ Day Composite Resin Poly Carboxylate Cement (500 gms Pack):40 Packs/ Day Plant & machinery: 26 lakhs
Working capital: -T.C.I: Cost of Project: Rs 71 lakhs
Return: 33.00%Break even: 75.00%
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IV Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. Top 5 API producers account for approximately 6.5 %. The leading APIs are anti-infectives, gastrointestinal, cardiovascular and respiratory drugs. The Chemical Pharmaceutical Generic Association (CPA) projects that India's share of the world API market will grow by 10.5% by 2010 as patented blockbuster drugs lose their patent protection. The CPA also expects that the domestic Indian market for APIs, both generic and branded, will rise from USD 755 mn in 2005 to USD 1.9 bn in 2010.
Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253 Lakhs
Working capital: N/AT.C.I: Cost of Project: 834 Lakhs
Return: 29.00%Break even: 52.00%
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Production of I.V. Fluids (Saline and Dextrose). Intravenous Solution (IV) Manufacturing Business with Blow-Fill-Seal (BFS) Technology.

Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. Infusion therapy as a basic toll of modern medical care enables the physician to restore and stabilize homeostasis states quickly and completely. In nursing homes and hospital where patients are suffering from acute dehydration or considerable debilitating conditions, the intra venous fluids are used as I.V. drips. The basic function of I.V. fluids is to replenish the body fluids. Although there are a number of I.V. fluids but generally three types of I.V. fluids are used in hospitals as I.V. drips. Uses and Applications There are main ranges of application of highly specialized intravenous infusion solutions: • Treatment of discarded water and electrolyte metabolism, especially in severe cases. • Therapy of acid base in balances. • The volume substitution and volume replacement in surgery of accident victim suffering blood loss. • Paratral nutrition for severally ill and post-operative patients. • Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and haemorrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to delI.V.er a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood. They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not. Intravenous Fluids Market is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. The rising popularity of intravenous vitamin C therapy in cancer treatment is one of the major trends in the intravenous solutions market. The intravenous vitamin C solution has been observed to have an increased toxicity to cancer cells and improve the patients' quality of life. Intravenous fluids are extensively used to treat electrolyte imbalances, maintain fluid balance, and replace fluid losses. These fluids are dispensed in volumes ranging from 25-1,000 milliliters and are available in either plastic bags or glass bottles. A complete mixture of all essential nutrients is also available in multi-chamber bags, and these bags are gaining immense popularity among numerous end-users. The global Intravenous (I.V.) solutions market was valued at USD 6.9 billion in 2015 and is projected to grow at a CAGR of 7.8% over the forecast period. The emergence of this market is attributed to the fast growing geriatric population and prevalence of malnutrition in the elderly and pediatric population. Blow-Fill-Seal (BFS) Technology In blow-fill-seal (BFS) technology, which is a form of advanced aseptic manufacturing, the container is formed, filled, and sealed in one continuous, automated system. A primary advantage of this technology is reducing human intervention, which reduces the risk of microbial contamination and foreign particulates. BFS has long been used in liquid pharmaceutical applications, including small containers, such as ophthalmic and respiratory drug ampoules, as well as larger volume containers, such as saline or dextrose solutions. More recently, BFS technology has been expanding into injectable and into biologics, including vaccines and monoclonal antibodies (mAbs). Advantages of BFS Technology: • Blow-fill-seal technology enables the manufacture of preservative-free single-unit doses. PreservatI.V.es are recognized as potentially harmful to the sensitive mucosae of the eyes, nose, and lungs, so this is an enormous benefit to sensitive patients. • Another advantage of unit-doses is that they ensure that the patient takes the correct amount of product, especially when dealing with highly potent compounds, i.e. those therapeutically active at a low concentration. • Sterile unit-doses are portable and easy to use individually, excellent properties for today’s active lifestyles. Blow-fill-seal (BFS) single doses are an ideal solution for use in ophthalmology, respiratory diseases, rhinology, antisepsis and wound care. • Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilised by autoclaving as polypropylene has greater thermostability. • Blow Fill and Seal technology is mainly used for pharmaceutical solutions. The examples of pharmaceutical solutions that can be packaged are injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for dialysis, solutions for irrigation and solutions for hemofiltration. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms. The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. The process begins with the Extrusion of plastic granules in the form of a hot hollow pipe of molten plastic called a parison. The following step is the Blow moulding of the container from the plastic granule. The parison is closed between the mould, and the container gets formed either by blowing sterile compressed air or by vacuum or by using vacuum as well as blowing. The container assumes the shape of the cavity in the mould. The container thus produced is open from the top and in its top part, the plastic is still hot and in molten state until the subsequent steps of filling and container sealing. The subsequent step is filling of the formed container from the top, which is still open (and still in a “hot molten” state). Filling nozzles enter from the top of container and filling is done. Filling nozzles are specially designed and constructed to facilitate automatic cleaning and automatic sterilization. Additional functions of filling nozzles are to blow the bottles and also to provide an exhaust path for air in the container. The filling process can be carried out under a shower of sterile filtered air to avoid contamination during filling. The blower on the sterile air shower can have variable pressure which can be made to change automatically so as to maintain constant air pressure under various situations. The sterile air shower is validated at certain air pressure, and an automatic device can maintain the same pressure by automatically modulating the speed of the blower. The next step is sealing the top of the container, which is still open and in a hot molten state. The top gets pressed between head moulds and as a consequence, the top part of the container gets formed, sealed and at the same time, gets cooled. The result is a hermetically sealed container. The final steps are for De-flashing to remove the flash or scrap, trimming the containers and delivering the containers outside the machine. The whole process of extrusion, blowing, filling, sealing and removing scrap takes between 10 to 18 seconds depending upon the type and size of the container. The advantage of the Blow-Fill-Seal process is derived mainly from the fact that container is formed, quickly filled and sealed under protected environment automatically without human intervention. BFS Machine Professional normal saline I.V. fluids packaging machine is the latest production line with most advanced technology. It can automatically finish film feeding, printing, bag making, filling and sealing in one machine. This BFS line can be used to automatically fill 50-5000ml general solution, special solution, dialysis solution, parenteral nutrition, Antibiotics, Irrigation and Disinfectant solution etc. Features: 1. 100% film utilization: No waste edge between bags, reducing both material and energy consumption. 2. Special I.V. bag design: each bag saves 10mm film than others. 3. Reliable heating and welding system: Leakage rate less than 0.03%. 4. Quick changeover: 0.5-1 hour to switch from one size to another. 5. Stable transmission system: only needs 1 control system, 1 HMI and 1 operator. 6. Safe filling nozzle: No solution overflows, no particles generation. 7. Auto faulty rejection system detected by the machine. 8. Production line length is reduced by 1/3, both workshop and air conditioning and cleaning area are reduced by 1/3, greatly reducing the initial investment and future running cost. 9. Simple structure, more stable and reliable performance. Tags I.V. 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Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253.00 Lakhs
Working capital: N/AT.C.I: Cost of Project 834.00Lakhs
Return: 29.00%Break even: 52.00%
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I.V. Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Intravenous fluids can also be used as a route of medication administration. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. These new business streams would help growth in future earnings. Intravenous (IV) fluids market in India is around Rs. 3,000 crore growing at healthy rate of around 15-20 per cent a year due to its essential requirement in nature. Which facilitates the development of new technologies and ensure a high quality product. Few Indian major players are as under • Abaris Healthcare Pvt. Ltd. • Ahlcon Parenterals (India) Ltd. • Axa Parenterals Ltd. • Infutec Healthcare Ltd. • Kokad Pharmaceutical Laboratories Ltd. • Parenteral Surgicals Ltd. • Punjab Formulations Ltd.
Plant capacity: I.V. Fluid (500 ml.): 48000 Bottles /DayPlant & machinery: Rs 252 lakhs
Working capital: N/AT.C.I: Cost of Project: Rs 833 lakhs
Return: 29.00%Break even: 52.00%
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Ready Mix Coating Powder Used for Coating of Pharmaceuticals Tablets for Regular fill Coating and Functional Film Coating

In pharmaceutical drug delivery of solid oral dosage forms film coatings are frequently applied. The motivation for coating dosage forms range from cosmetic considerations (colour, gloss), improving the stability (light protection, moisture and gas barrier) and making it easier to swallow the tablet. In addition, functional coatings can be used to modify the drug release behaviour from the dosage form. A film coating is a thin polymer-based coat applied to a solid dosage form such as a tablet. The thickness of such a coating is usually between 20-100 µm. The Indian excipient market is expected to grow at the rate of 10–12 percent until 2020. the excipients are priced at 5–7 percent lesser in India v Which facilitates the development of new technologies and ensure a high quality product. Few Indian major players are as under • A D C L Drugs & Chemicals Ltd. • Anmol Drugs & Pharmaceuticals Ltd. • Avinash Drugs Ltd. • Beryl Drugs Ltd. • Bio-Caps India Ltd. • Bio-Ethicals Pharma Ltd. • Biochem Pharmaceutical Inds. Ltd
Plant capacity: Regular Film Coating Powder: 400 Kgs/Day Functional Fim Coating Powder: 400 Kgs/DayPlant & machinery: 19 lakhs
Working capital: -T.C.I: Cost of Project: Rs 172 lakhs
Return: 28.00%Break even: 59.00%
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Investment Opportunities in Calcium Gluconate Manufacturing Industry

Investment Opportunities in Calcium Gluconate Manufacturing Industry. Production of Calcium Gluconate. The global market for calcium gluconate is likely to expand due to the escalation in the demand from different end-use industries especially from food and beverages and pharmaceutical sectors. Calcium gluconate, a mineral supplement, is produced by the neutralization of gluconic acid with calcium carbonate or lime. It is used for treating conditions resulting from calcium deficiencies. These conditions include: hypocalcemia related to hyperparathyroidism, hypocalcaemia tetany, and hypocalcaemia associated with rapid growth or pregnancy. Besides its use as an active ingredient in medicines, it is also widely used in numerous food products, where it serves the role of a nutrient supplement. Calcium gluconate is a source of calcium in different varieties of foods and beverage, including: soft drinks, milk, bottled waters, juices, soy products, dairy products, confectionery, and baked goods. Calcium gluconate is extensively used in the treatment of Calcium deficiency, both for oral and parenteral administration. For Calcium therapy, Calcium gluconate is a well-established and most accepted drug in the medical field. Calcium in its ionic form has been shown to be an excellent therapeutic agent for the treatment of diseases caused and aggravated by deficiency of Calcium in the body. Calcium gluconate is being used as Tablets, intramuscular injections and as syrups. Calcium Gluconate forms a definite compound with Boric acid called Calcium Boro Gluconate which is more popular in the veterinary medical field. Calcium Boro Gluconate is used for the treatment of milk fever of milking cows. Uses: • Calcium gluconate is used to prevent and to treat calcium deficiencies. • Calcium gluconate may also be used for purposes not listed in this medication guide. • Calcium gluconate is being used as Tablets, intramuscular injections and as syrups. • It is used for treating conditions resulting from calcium deficiencies. Calcium Gluconate is used in the treatment of: • Heart Arrest • Hyperkalemia • Osteoporosis, Postmenopausal • Tetany Calcium Gluconate Market The global market for calcium gluconate is projected to grow as a result of the mounting demand from different end-use industries with the highest demand expected from pharmaceutical and food and beverages. Additionally, sunrise industries, such as nutraceuticals, have also largely stirred up demand for calcium gluconate globally. It is a major ingredient in various calcium-based health supplements. The global market for calcium gluconate can be segmented broadly based on application, end use, as well as the form available. Based on the end use, the market for calcium gluconate can be further segmented into: emulsifier, bulking agent, and thickening agent. Similarly, on the basis of application, the calcium gluconate market can be further bifurcated into: food & beverages, pharmaceuticals, and nutraceuticals. The mineral supplement is available in the following forms on the commercial market: gum, powder, and liquid. Calcium gluconate market has dominantly driven by its importance in medical treatment such as Calcium therapy. Its extensive use in injection and pharmaceutical medicines has increased the market demand. However, the various application markets with a significant demand for food and beverages are another major driver. Calcium gluconate is a biodegradable product, which has become additionally important for being environment-friendly. Despite its drivers, there are certain factors that affect the market growth such as the adverse health of calcium gluconate. Excessive consumption of calcium gluconate results in nausea, vomiting, constipation, decreased appetite and dry mouth that acts as a restraint for the market. Moreover, the different food regulatory constraints that hinder the product formulation and labeling requirements are also affecting the market. Global calcium gluconate market is expected to grow owing to increasing demand from end-use industries such as pharmaceutical and food & beverages. Sunrise industries like the nutraceutical industry has also largely impacted the global calcium gluconate market, as it finds itself as major ingredient in multiple calcium based health supplements. Increase in the demand for health supplements from the health conscious consumers has largely driven this market globally. More than 75% of Americans are calcium deficient, and more than one in 10 Americans either has, or is at risk of developing, osteoporosis or other bone diseases. Geographically, the global calcium gluconate market can be classified based on seven regions: Latin America, North America, Eastern Europe, Western Europe, Asia Pacific excluding Japan (APEJ), Japan, and the Middle East and Africa (MEA). The Asia Pacific region is projected to witness the highest growth thanks to increasing demand from the numerous end-use industries here. In addition, the growing government spending on infrastructure development will also help fuel the market’s growth through the forecast period. Tags Production of Calcium Gluconate, Manufacture of Calcium Gluconate, Calcium Gluconate Production, Preparation of Calcium Gluconate, Calcium Gluconate Manufacturing Plant, Calcium Gluconate Manufacture, Calcium Gluconate Industry, Manufacturing of Calcium Gluconate, How to Start Production of Calcium Gluconate, How to Start Calcium Gluconate Manufacturing Industry, Calcium Gluconate Manufacturing Business, Calcium Gluconate Production Plant, Calcium Gluconate Manufacturing Unit, Starting Your Own Calcium Gluconate Manufacturing Business, Production Process of Calcium Gluconate, Calcium Gluconate Production Project Ideas, Projects on Small Scale Industries, Small Scale Industries Projects Ideas, Calcium Gluconate Production Based Small Scale Industries Projects, Project Profile on Small Scale Industries, How to Start Calcium Gluconate Production Industry in India, Calcium Gluconate Production Projects, New Project Profile on Calcium Gluconate Production Industries, Project Report on Calcium Gluconate Production Industry, Detailed Project Report on Calcium Gluconate Production, Project Report on Calcium Gluconate Production, Pre-Investment Feasibility Study on Calcium Gluconate Production, Techno-Economic Feasibility Study on Calcium Gluconate Production, Feasibility Report on Calcium Gluconate Production, Free Project Profile on Calcium Gluconate Production, Project Profile on Calcium Gluconate Production, Download Free Project Profile on Calcium Gluconate Production, Industrial Project Report, Project Consultant, Project Consultancy, Startup Project for Calcium Gluconate Production
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Return: 1.00%Break even: N/A
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Cenosphere Processing Plant

Cenosphere Processing Plant. Cenosphere Separation from Fly Ash. Production of Cenospheres from Coal Fly Ash. Cenospheres are inert, light weight and hollow spheres particularly made of alumina or silica and filled with inert gases or air. They are typically manufactured as a by-product of coal combustion in the thermal power plants. Cenospheres are hollow, low-density, spherical, and free-flowing aluminosilicate microspheres that are produced as a by-product of coal ignition at the coal-fired power plants. It is a rich-in-ceramic industrial waste formed at the time of coal combustion in the thermal power plants. Inside the each sphere there is a near vacuum that produces good properties of thermal and acoustic insulation making a product ideal for automotive acoustic insulation applications where the mass is a major factor to be considered. These spheres are used globally in several automotive application including tyres, brake linings, friction linings, dashboard, and clutch facings. The broad range of usage has increased the demand of cenosphere suppliers India in the industry. Cenospheres, the high strength, small sized, lightweight, non-porous, free flowing, hollow ceramic spheres produced in coal fired thermal power plants during the burning of lignite or coal at very elevated temperatures, find extensive usage across a number of industries owing to their physical properties. Cenospheres find usage as fillers in a number of applications, replacing resins and minerals and imparting diverse benefits such as reduced shrinkage, improved level of thermal insulation, weight reduction, improved level of fire resistance, and easier application. Uses of Cenosphere: Cenospheres in Paints and Coatings There are a great many uses for cenospheres in the paint and industrial coating industry, due to the additional qualities they provide. For example, cenospheres are often used in coatings to control infrared radiation, giving those coatings an advantage over ones that merely attempt to limit thermal conductivity. Cenospheres in Syntactic Foams Cenospheres are often used to make ‘syntactic foams’. These are specialized solids which use cenospheres as a filler to provide any number of advantages, from lower cost, to added strength, sound proofing, buoyancy and thermal protection. Cenospheres in Plastics and Polymers Cenospheres also have a use in the manufacture of plastics and polymers, as their re-formable shape or strength helps to avoid shrinkage in thermoplastics and thermosetting plastics. Cenospheres in Pharmaceuticals Cenospheres have been used in the pharmaceutical industry for many years, as the small balls can act as a near-perfect transport device when coated with drugs. Cenospheres in Advanced Industries Cenospheres are also being used in the development of metal matrix composites (MMC), a variety of materials that attempts to combine the high energy absorption, impact resistance, and low density of the spheres with the qualities of other substances. Market Outlook Cenospheres are providing emerging opportunities along with the future effects of major drivers and challenges that support the managers to make cost-effective decisions in favor of the business. The increasing demand from end-use industries including refractory, construction, paints and coatings, and oil and gas, which is expected to take the market to the next level in the near future. However, restricted sources of raw material and deficiency of quality control across developing countries are key factors that may restrain the growth of the industry. The global cenospheres market was valued at USD 346.8 Million in 2016 and is projected to reach USD 689.2 Million by 2022, at a CAGR of 12.16% from 2017 to 2022. The growing demand from end-use industries, such as paints & coatings, refractory, construction, and oil & gas is expected to drive the market in near future. However, limited sources of raw material and lack of quality control across emerging countries are major factors that may restrain the growth of the market. The Gray Cenospheres segment is estimated to experience the highest growth in the upcoming years because of its wide uses across the industrial segment. The demand will increase also because the gray cenosphere is produced more frequently as compared to the white cenosphere in fly ash. The demand for gray cenosphere suppliers India is rising because they deliver quality material which contains a low content of alumina and is high in silica and iron content that is used in a number of applications such as plastics, concretes, coatings, resins, bricks, and rubbers. The gray cenospheres segment is expected to witness the highest growth from 2017 to 2022, as they are widely used across industries. Gray cenospheres occur more frequently than white cenospheres in fly ash. These cenospheres have low content of alumina and high content of silica and iron. Gray cenospheres are used in various applications, such as concretes, plastics, resins, coatings, bricks, and rubbers. North America is projected to be the fastest-growing cenospheres market during the forecast period, due to the growing oil & gas and automotive industries in the region. The market in Middle East & Africa, Asia-Pacific, and South America is also expected to witness significant growth, due to growing demand for cenospheres from the oil & gas and construction industries in these regions. Industries such as oil and gas, building, plastics, aerospace, automotive, and surface coating continue to be some of the leading consumers of cenospheres and new application areas are being devised at an encouraging pace. Owing to their natural properties, cenospheres can be used in forms such as dry, wet, or slurry. Owing to their inert nature, cenospheres are not affected by acids, alkalis, water, or solvents. Hence, cenospheres have an impressive reusability quotient. Cenospheres are nearly 30% lighter than conventionally used resins and nearly 75% lighter than most minerals used as fillers or extenders. The main application of cenospheres as bulk fillers in all the end-user industries is expected to act as catalysts for the growth of the overall cenospheres market over the forecast period. Moreover, as cenospheres are small in size and have great compressive strength they are used as a structural lightweight filler, thus the cenospheres market is expected to see rapid growth in all developed and developing countries in the future. The cenospheres market can be segmented as: • Automotive • Construction • Oil & Gas • Paints & Coating • Others (Refractory, Bulk Fillers, Etc.) Cenospheres find a wide range of applications in the construction, oil & gas and infrastructure industry and are used in commercial, industrial, residential and infrastructure construction projects. The growing construction industry output is expected to be one of the most significant factors for increased demand of cenospheres in the global market. Rapid urbanisation is leading to new construction activities, which is further expected to boost the demand of cenospheres in building and construction tasks. Moreover, growing urbanisation is expected to contribute to the growth of the global cenospheres market at a CAGR close to or below the global GDP growth over the forecast period. The market is becoming healthier for competitions, which is a positive factor influencing the cenospheres manufacturers. The growth of technology and automation in the manufacturing and supply of all automobiles has further increased its attractiveness among the consumers and all end-use industries. Prominent market players are trying to develop strong, long-lasting and lightweight cenospheres for all the vehicles in the automotive industry, which can be used efficiently and sustain load depending on the vehicle type. The advancement in the material science technologies in the manufacturing industries have enabled them to use new invented materials, such as alloys of steel and aluminium, which make the cenospheres of the vehicles stronger and durable under extreme load conditions. Tags Cenosphere Processing, Cenosphere Processing Plant, Cenospheres from Fly Ash, Cenosphere Processing Project, Fly Ash to Cenospheres Process, Cenosphere Manufacturing Process, Cenosphere Separation from Fly Ash, Cenosphere Manufacture, Production of Cenospheres, Cost Of Manufacturing Plant for Cenosphere, Production of Cenospheres from Fly Ash, Separation of Cenosphere from Fly Ash, Cenosphere Manufacturing, Lightweight Cenosphere Processing, Cenosphere Production, Cenosphere Manufacturing Plant, Cenosphere Manufacturing Company, Cenospheres Industry, Cenosphere Processing project ideas, Projects on Small Scale Industries, Small scale industries projects ideas, Cenosphere Processing Based Small Scale Industries Projects, Project profile on small scale industries, How to Start Cenosphere Processing Industry in India, Cenosphere Processing Projects, New project profile on Cenosphere Processing industries, Project Report on Cenosphere Processing Industry, Detailed Project Report on Cenosphere Processing, Project Report on Cenosphere Processing, Pre-Investment Feasibility Study on Cenosphere Processing, Techno-Economic feasibility study on Cenosphere Processing, Feasibility report on Cenosphere Processing, Free Project Profile on Cenosphere Processing, Project profile on Cenosphere Processing, Download free project profile on Cenosphere Processing, Industrial Project Report
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Return: 1.00%Break even: N/A
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Production of Crosslinked Sodium Carboxymethyl Cellulose

Production of Crosslinked Sodium Carboxymethyl Cellulose. Cross-Linked CMC Manufacturing Industry. Cross-Linked Sodium Carboxymethyl Cellulose Manufacturing Project. Croscarmellose Sodium or Modified Cellulose Gum Cross-linked sodium carboxymethyl cellulose is also known as croscarmellose sodium or modified cellulose gum. Cross-linked sodium carboxymethyl cellulose is semi synthetic polysaccharide that consists of glucose monomer chains which form a major component of plant cell walls and fibres. Crosslinked sodium carboxymethylcellulose (CMC), croscarmellose, is prepared by the reaction of Na-CMC with acids. Croscarmellose is used as dietary supplements, sweetener tablets, and medicines. The chapter provides nutritional properties of crosslinked sodium CMC. Cross-linked sodium carboxymethyl cellulose is manufactured by acidifying an aqueous suspension of sodium carboxymethyl cellulose and heating the suspension to achieve cross-linking. The product is then washed and dried. It is also produced during the manufacture of sodium carboxymethyl cellulose by lowering the pH and heating to cause cross-linking. Cross-linked sodium carboxymethyl cellulose is used in tablets of table-top sweeteners and dietary food supplements, as it facilitates disintegration in aqueous solutions, with a maximum level of use of 30 g/kg. It is also widely used as an excipient in pharmaceutical applications. Uses: Cross-linked sodium carboxymethyl cellulose is used in tablets of table-top sweeteners and dietary food supplements, as it facilitates disintegration in aqueous solutions, with a maximum level of use of 30 g/kg. It is also widely used as an excipient in pharmaceutical applications. Cross-linked sodium carboxymethyl cellulose is used in food as an emulsifier to maintain a uniform mixture between two or more unblendablemixutres. A mixture of oil and water. Used in many products including pasteurised products, ice-creams, cheeses, dairy products, batters, baked emulsions and spreads, breakfast cereals, and bakery goods. Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application. It did not cause infection, extrusion, migration, or adverse reactions in the patients who have been followed for two years. Delayed aesthetic results on facial wrinkles were very satisfactory. Cross-linked sodium carboxymethyl cellulose was originally developed as a tablet disintegrant for medicinal products and dietary food supplements, allowing dissolution at low use levels (0.25-3.0%). It has an official monograph in the European Pharmacopoeia. In the USA, it is used as a disintegrant in prescription drugs and has generally recognized as safe (GRAS) status for use in dietary supplements. Few Indian major players are as under • Hexone Pharmaceuticals Ltd. • Hiranya Chemicals Pvt. Ltd. • Maple Biotech Pvt. Ltd. • Perry Impex Ltd. • Rishi Trading Co. Ltd. • Shreejal Info Hubs Ltd. Market Outlook The growth of processed food industry, increasing pharmaceutical and cosmetics production, and the growing oil drilling activities are the major factors driving the growth of CMC market. The increasing disposable income in emerging economies such as China, India, Mexico, Africa and South America has led to increasing consumption of processed food. CMC is widely used as binder, thickener, bulking agent, and suspension agent in several food and beverages applications. The segment accounted for a share of 31.0% of the global CMC market, in terms of volume consumed in 2014. The major factor restraining the CMC market growth is the emergence of substitutes in various applications. Guar gum can substitute in CMC in majority of the applications. The organic/green label associated with guar gum is an added advantage for the product to replace CMC in several applications. The global carboxymethyl cellulose (CMC) market was estimated at $1,151.7 Million in 2014 and is projected to register a CAGR of 4.2% between 2015 and 2020. Carboxymethyl cellulose (CMC) or cellulose gum is a cellulose derivative with carboxymethyl group in its chain. CMC is physiologically inert, chemically stable, odorless and tasteless substance which safe for health and environment. The other properties of CMC include high viscosity, non-toxic nature, and hypoallergenic. Major raw materials used in manufacture of carboxymethyl cellulose (CMC) include plant derived cellulose, caustic soda, and monochloroacetic acid. CMC is widely used as thickener, stabilizer, binder and dispersant in variety of applications such as food and beverages, pharmaceutical and cosmetics, detergents, oil and gas, paper processing and others. Carboxymethyl cellulose can be defined as an additive used for improving product and processing characteristics in various fields, such as pharmaceuticals and food processing industry. Carboxymethyl cellulose is often used in forms such as sodium salt, sodium carboxymethyl cellulose. Sodium carboxymethyl cellulose is also used as a viscosity modifier or thickener, and to stabilize emulsions in various products including consumer goods and other major end-use industries. Geographically Asia-Pacific dominated sodium carboxymethyl cellulose market driven in terms of production and consumption driven by higher demand into major end use industry in the region. Asia-Pacific was followed by North America and Europe as second and third largest market for sodium carboxymethyl cellulose market. Asia Pacific is projected to have fastest growth, owing to rapidly increasing and expanding industrial base leading to higher demand of sodium carboxymethyl cellulose. Carboxymethyl cellulose is also popular for its excellent water retaining capacity amongst the major end-use industries apart from this other properties which makes sodium carboxymethyl cellulose more popular are resistant to oils, greases, and organic solvents. Sodium carboxymethyl cellulose is synthesized by the reaction of chloroacetic acid with cellulose. Tags Cross-Linked CMC Manufacturing Industry, Croscarmellose Sodium or Modified Cellulose Gum, Cross-Linked Sodium Carboxymethyl Cellulose, Uses of Cross-Linked Sodium Carboxymethyl Cellulose, Application of Cross-Linked Sodium Carboxymethyl Cellulose, Process for Producing Sodium Carboxymethylcellulose, Production of Croscarmellose Sodium, Production of Crosslinked Sodium Carboxymethyl Cellulose, Cross-Linked CMC Manufacturing Industry, Cross-Linked Sodium Carboxymethyl Cellulose Manufacturing Project, Crosslinked Sodium-CMC, Preparing Cross-Linked Sodium Carboxymethyl Cellulose, Use of Cross-Linked Carboxymethyl Cellulose for Soft-Tissue Augmentation, Cross-Linked Sodium Carboxymethyl Cellulose Manufacturing Project Ideas, Production of Modified Cellulose Gum, Projects on Small Scale Industries, Small scale industries projects ideas, Cross-linked Sodium Carboxymethyl Cellulose Manufacturing Based Small Scale Industries Projects, Project profile on small scale industries, Cross-linked Sodium Carboxymethyl Cellulose Projects, New project profile on Cross-linked Sodium Carboxymethyl Cellulose Production, Project Report on Cross-linked Sodium Carboxymethyl Cellulose, Detailed Project Report on Cross-linked Sodium Carboxymethyl Cellulose Production, Pre-Investment Feasibility Study on Cross-linked Sodium Carboxymethyl Cellulose Production, Techno-Economic feasibility study on Cross-linked Sodium Carboxymethyl Cellulose Production, Feasibility report on Cross-linked Sodium Carboxymethyl Cellulose, Free Project Profile on Cross-linked Sodium Carboxymethyl Cellulose Manufacturing Business, Project profile on Cross-linked Sodium Carboxymethyl Cellulose, Download free project profile on Cross-linked Sodium Carboxymethyl Cellulose, Industrial Project Report, Project consultant, Project consultancy, Business consultancy, Business consultant, Project identification and selection, Preparation of Project Profiles, Startup, Business guidance, Business guidance to clients, Startup Project for Cross-linked Sodium Carboxymethyl Cellulose Production
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Return: 1.00%Break even: N/A
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