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Pharmaceutical, Drugs, Fine Chemicals, Bulk Drug Intermediates, Pharmaceutical Drugs, Pharma Drug Ingredients Intermediates, Drug Intermediates, Speciality Chemicals, Raw Materials, Fine and Specialty Chemicals Intermediates, Pharmaceutical Bulk Drugs

Indian drugs and pharmaceutical industry has advanced perceptibly and is getting ready  for the new patent regime and  to withstand global competition, which is expected to be unleashed by new winds of liberalisation - a new era of liberalisation - much different from what was ushered in since the conclusion of the Uruguay Round and the establishment of the World Trade Organisation.

The industry has been expanding at annual rates ranging between 8 to 10% (against global growth rate of 6%).  According to a study  by McKinsey, Vision 2010, the domestic pharmaceutical industry could attain a size of  $25 billion (Rs 1200 billion) by 2010 by focusing on two areas: first, innovation-led research, development and new drug discoveries; and second, information technology-led remote sales and marketing.  The market for bulk drugs and formulations had increased from about Rs 103  billion in 1990-91 to an estimated Rs 435  billion at the end of 2003-04.  The prices of Indian essential drugs are among the lowest in the world. Apart from strides made by the industry in the last half-a-century, lower production cost due to reverse engineering and low R&D outlays has been a major factor in keeping the prices under check.

The global pharmaceutical industry is estimated at $ 300 billion, not all representing cross-border trade.  India's measly share of $ 1.5 billion in global trade represents an untapped potential. Under the regime of economic liberalisation underway since early 1990s, the drugs and pharmaceutical sector witnessed initiatives at fresh investment in the sector. Nearly 1735 investment proposals of the order of around Rs 166  billion were initiated. The foreign collaboration proposals approved numbered around 425 with a foreign direct investment  (FDI) component of over Rs 25 billion. The pharmaceuticals have figured high on the export front. In 2001-02,  the sector was  estimated to have registered a growth of 17.6% at around Rs 20.3 billion.

In the wake of economic liberalisation, many a  overseas players  returned or contemplated returning to India. These include Ivox Corp (USA),  Taro Pharmaceuticals (Israel) and Merck (USA). These are out either to set shop or looking for acquisitions in India. Hexal AG of Germany has established a liaison office in India. MILLIONCs like Rocha, Bayer, Aventis and Chiron are making India a regional hub for bulk drugs. 

The Export Import Bank of India (Exim Bank) had  doubled its corpus for the pharmaceutical industry to Rs 2 billion as a result of increased activity in the industry, especially in the external sector. The fund is used for the development and commercialisation of the new products and applications, significant improvement in the existing design of  products, setting up and expansion of pilot plants, research studies for obtaining regulatory approvals, cost of filing and managing international patent and R&D Centres.

It needs, however, to be recognised that the presence  of small scale manufacturers has resulted, on the one hand,  in a highly fragmented industry, and on the other, it has made it possible to supply a near 100,000 drugs including vitamins, antibiotics, antibacterials, cardio-vascular and other essential drugs. These account for nearly 37% of the market.  While each of about 80% of the manufacturers has annual sales below a billion rupees, top ten companies are known to control over 30% of the market. At present there are more than 20,000 players in the country.

The major players are: Alembic Chem, Aurobindo Pharma, Cipla, Dr. Reddy's, FDC, IPCA Labs, Jagsonpal Pharma, J.B. Chemicals, Kopran, Lupin Labs, Lyka Labs, Morepan Labs, Nicholas Piramal, Ranbaxy Labs, Sun Pharma, Themis Medicare, GlaxoSmithkline, Astrazeneca, Aventis, E-Merck, Torrent Pharma, TTK Healthcare, Unichem Labs,  Wockhardt  and  Zandu Pharma.  Until recently, only a few of the Indian companies had gone into any serious R&D activity. Much of the effort was directed to affordable analogue research. The R&D level in the country is low with even well-placed pharma companies spending less than 2% of turnover on R&D. MILLIONCs are known to contribute as much as 10% or more of their turnover to R&D.  While India is very strong in process chemistry, biology and applied bio-chemistry, initiatives at all levels - government, academia, private sector - involving heavy financial outlays, are called for.

Ayurveda continues to remain a preferred system of medicine for a vast segment of population in the country. The country has over 400,000 registered practitioners of the Indian system of medicine. Around 170 institutes properly affiliated to various universities impart under- or post-graduate courses each year. These institutes churn out some 5,500 fresh practitioners. The practitioners are supported by 12,000 dispensaries and 2,100 beds available for ayurveda treatment countrywide. The emerging biotechnology sector has already taken by storm and is offering sops to states to make these as the thriving ground for the highly potential segment in medicare.

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Production of Paracetamol (Acetaminophen) Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain. The quality of the evidence regarding the use for fever relief in children is poor. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hours. Paracetamol lacks anti-inflammatory action in rheumatic disorders. However, it is less toxic than the Aspirin and does not produce anemia and liver damage, which sometimes result from the continued use of acetanilide and acetophenotidine. It is also an important intermediate in the manufacture of other pharmaceuticals like the antimalarial amodiaquine. Few Indian Major Players are as under: • Alta Laboratories Ltd. • Granules India Ltd. • HaffkineAjintha Pharmaceuticals Ltd. • Pan Drugs Ltd. Market Outlook The pharmaceutical industry in India ranks 3rd in the world terms of volume and 14th in terms of value. 20% of global exports in generics, making it the largest provider of generic medicines globally. USD 45 Billion in revenue by 2020, revenue of USD 55 billion by 2020 as base case, and can grow to USD 70 billion in an aggressive case scenario. USD 26.1 Billion in generics by 2016. USD 200 Billion to be spent on infrastructure by 2024. Global acetaminophen market was valued at around USD 801.3 million in 2014 and is expected to reach USD 999.4 million in 2020, growing at a CAGR of around 3.8% between 2015 and 2020. In terms of volume, the global acetaminophen market stood at above 149.3 kilo tons in 2014. The global paracetamol market is expected to reach US$1,049.7 mn by 2022 as compared to its valuation of US$900.2 mn in 2014. Tags Paracetamol Manufacturing Plant, Paracetamol Production, Paracetamol Manufacturing, Paracetamol Manufacturing Process, Production of Paracetamol, Paracetamol Production Process, Manufacturing of Paracetamol Tablets, Paracetamol Manufacture in India, Manufacture of Paracetamol, Paracetamol Manufacturing Unit, Pharmaceutical Industry, Production Plant of Paracetamol, Pharmaceutical Manufacturing Business, Production Process of Paracetamol, Acetaminophen Manufacture, Manufacturing Plants of Paracetamol, Acetaminophen Manufacturing Plants, Industrial Production of Paracetamol, Business Plan for Acetaminophen Manufacturing, Paracetamol Manufacturing Business, Paracetamol Manufacturing Industry, Production of Acetaminophen Production Plant of Paracetamol, How to Prepare Paracetamol, Manufacturing and Formulation of Paracetamol, Paracetamol Manufacturing Project Report, Method for Manufacturing of Paracetamol, Method for Production of Paracetamol, Paracetamol Production Method, Manufacturing Method of Paracetamol, Production Plan for Paracetamol, Manufacturing Business of Paracetamol, Business Ideas for Manufacturing of Paracetamol, Small Scale Paracetamol Manufacturing Business Ideas & Opportunities, Process for Producing Paracetamol, Preparation Method for Paracetamol, Profitable Paracetamol Manufacturing Business, Start Production of Paracetamol, Paracetamol Manufacturing Process in India, How to Make Paracetamol, Method of Making Paracetamol, Drugs Manufacturing Project, Drugs Manufacturing Plant, Drugs Production, Paracetamol Manufacturing Project Ideas, Projects on Small Scale Industries, Small Scale Industries Projects Ideas, Paracetamol Manufacturing Based Small Scale Industries Projects, Project Profile on Small Scale Industries, How to Start Acetaminophen Manufacturing Industry in India, Paracetamol Manufacturing Projects, New Project Profile on Paracetamol Manufacturing Industries, Project Report on Acetaminophen Manufacturing Industry, Detailed Project Report on Paracetamol Production, Project Report on Paracetamol Manufacturing, Pre-Investment Feasibility Study on Paracetamol Manufacturing, Techno-Economic Feasibility Study on Paracetamol Manufacturing, Feasibility Report on Paracetamol Manufacturing, Free Project Profile on Paracetamol Production, Project Profile on Acetaminophen Manufacturing, Download Free Project Profile on Paracetamol Production, Industrial Project Report, Project Consultant, Project Consultancy, NPCS, Niir, Process Technology Books, Business Consultancy, Business Consultant, Project Identification and Selection, Preparation of Project Profiles, Startup, Business Guidance, Business Guidance to Clients, Startup Project for Paracetamol Manufacturing, Startup Project, Startup Ideas, Project for Startups, Startup Project Plan, Business Start-Up, Business Plan for Startup Business, Great Opportunity for Startup, Small Start-Up Business Project, Project Report for Bank Loan, Project Report for Bank Finance, Project Report Format for Bank Loan in Excel, Excel Format of Project Report and CMA Data, Project Report Bank Loan Excel, Detailed Project Plan Reports
Plant capacity: Paracetamol Tablets: 1500mt/annum Paracetamol Powder: 420mt/annumPlant & machinery: 349 Lakhs
Working capital: -T.C.I: 863 Lakhs
Return: 27.00%Break even: 46.00%
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Production of Paracetamol (Acetaminophen) Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. It is typically used for mild to moderate pain. The quality of the evidence regarding the use for fever relief in children is poor. It is often sold in combination with other ingredients such as in many cold medications. In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery. It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hours. Paracetamol lacks anti-inflammatory action in rheumatic disorders. However, it is less toxic than the Aspirin and does not produce anemia and liver damage, which sometimes result from the continued use of acetanilide and acetophenotidine. It is also an important intermediate in the manufacture of other pharmaceuticals like the antimalarial amodiaquine. Few Indian Major Players are as under: • Alta Laboratories Ltd. • Granules India Ltd. • HaffkineAjintha Pharmaceuticals Ltd. • Pan Drugs Ltd. Market Outlook The pharmaceutical industry in India ranks 3rd in the world terms of volume and 14th in terms of value. 20% of global exports in generics, making it the largest provider of generic medicines globally. USD 45 Billion in revenue by 2020, revenue of USD 55 billion by 2020 as base case, and can grow to USD 70 billion in an aggressive case scenario. USD 26.1 Billion in generics by 2016. USD 200 Billion to be spent on infrastructure by 2024. Global acetaminophen market was valued at around USD 801.3 million in 2014 and is expected to reach USD 999.4 million in 2020, growing at a CAGR of around 3.8% between 2015 and 2020. In terms of volume, the global acetaminophen market stood at above 149.3 kilo tons in 2014. The global paracetamol market is expected to reach US$1,049.7 mn by 2022 as compared to its valuation of US$900.2 mn in 2014. 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Plant capacity: Paracetamol Tablets: 1500mt/annum Paracetamol Powder: 420mt/annumPlant & machinery: 349 Lakhs
Working capital: -T.C.I: 863 Lakhs
Return: 27.00%Break even: 46.00%
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I.V. Fluids

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenousadministration. I.V. fluids or Intravenous fluids are life saving drugs, which are widely used in surgery, pediatrics, urology, obstetrics and gynecology. They are given mostly to patients suffering from dehydration, diarrhoea, vomiting, gastroenteritis and excessive perspiration. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. Thus, due to demand it is a good project for entrepreneurs to invest. Few Indian Major Players are as under • AxaParenterals Ltd. • D.J. Laboratories Pvt. Ltd. • Baxter International Inc. • Amanta Healthcare • Aishwarya Healthcare
Plant capacity: I.V. Fluid (500 ml.):14,400,000 Bottles/annumPlant & machinery: Rs 476 lakhs
Working capital: -T.C.I: Cost of Project: Rs 1092 lakhs
Return: 26.00%Break even: 53.00%
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Surgical Cotton

Cotton is a soft, staple fiber that grows in a form known as a boll around the seeds of the cotton plant, as shrub native to tropical and subtropical regions around the world, including the Americas, India and Africa. Surgical cotton is also known as absorbent cotton” or “cotton wool”. Surgical/Absorbent cotton is cleared de-oiled and bleached cotton packed in different sizes. The fiber of Surgical/Absorbent cotton is very elastic. It consists of 98%-99.5% of cellulose which has a diameter of 16.30 and a length of 12-40 mm. Today, India produces the widest range of cotton; perhaps no other cotton producing country in the world has this distinction. The demand of Surgical Absorbent Cotton is directly related with the increase in population and expansion of public health services. Government hospitals and large nursing homes are the largest consumer for cotton wool. the area under surgical cotton cultivation in India was 97 percent in 1947, it fell to 42 percent in 1990, 28 percent in 2000 and about 1 percent in 2012, and it is now estimated to be much less than 1 percent. Meditech in India is expected to grow at a CAGR of 9.1% from US$ 600 million in 2014 to US$780 million in 2017. As a whole any entrepreneur can venture in this project without risk and earn profit. Few Indian major players are as under • Jajoo Surgicals Pvt. Ltd. • Mohini Fibers Limited • Pradeep Surgical Dressings Pvt. Ltd. • Medicare Healthcare Product • Bafna Healthcare Pvt. Ltd. • BVM Meditech Private Limited
Plant capacity: 1300 Kgs/day Plant & machinery: 191 lakhs
Working capital: -T.C.I: Cost of Project: Rs 278 lakhs
Return: 26.00%Break even: 64.00%
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Dental Materials (Alginate, GI Cement, Composite Resin & Polycarboxylate Cement)

A dental impression is a negative imprint of hard (teeth) and soft tissues in the mouth from which a positive reproduction (cast or model) can be formed. Impression material is of liquid or semi-solid nature when first mixed and placed in the mouth. It then sets to become an elastic solid (usually takes a few minutes depending upon the material), leaving an imprint of person's dentition and surrounding structures of oral cavity. Alginate is an irreversible hydrocolloid. It exists in two phases: either as a viscous liquid, or a solid gel, the transition generated by a chemical reaction. The overall setting double composition reaction is as follows: Potassium (sodium) alginate + calcium sulphate dihydrate + water ? calcium alginate + potassium (sodium) sulphate Sodium phosphate is added as a retarder which preferentially reacts with calcium ions to delay the set of the material. The market has been estimated at USD 6.2 billion in 2016 and is projected to reach USD 8.5 billion by 2021, at a CAGR of 6.5% during the forecast period from 2016 to 2021. Dental equipment is tools used to diagnose and treat dental diseases. Dental tools are used by dental professionals to examine, manipulate, restore and remove teeth and surrounding oral structures and to provide dental treatment. The end-users for this market include hospitals, dental clinics, and dental practitioners. The Global Restorative Dentistry Market is projected to Reach USD 21.27 Billion by 2022 from USD 15.60 Billion in 2017, at a CAGR of 6.4% Increase in the prevalence of dental diseases (dental caries and edentulism), rising demand for advanced cosmetic dental procedures, growing dental tourism, and increasing dental expenditure are the major factors driving the demand for restorative dentistry. As a whole any entrepreneur can venture in this project without risk and earn profit.
Plant capacity: Composite Resin Poly Carboxylate Cement (500 gms Pack): 80 Packs/ Day Glass Ionomer Cement (15 gms Packs with 10 gm Liquid): 1333 Packs/ Day Composite Resin Poly Carboxylate Cement (500 gms Pack):40 Packs/ Day Plant & machinery: 26 lakhs
Working capital: -T.C.I: Cost of Project: Rs 71 lakhs
Return: 33.00%Break even: 75.00%
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IV Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. Top 5 API producers account for approximately 6.5 %. The leading APIs are anti-infectives, gastrointestinal, cardiovascular and respiratory drugs. The Chemical Pharmaceutical Generic Association (CPA) projects that India's share of the world API market will grow by 10.5% by 2010 as patented blockbuster drugs lose their patent protection. The CPA also expects that the domestic Indian market for APIs, both generic and branded, will rise from USD 755 mn in 2005 to USD 1.9 bn in 2010.
Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253 Lakhs
Working capital: N/AT.C.I: Cost of Project: 834 Lakhs
Return: 29.00%Break even: 52.00%
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Production of I.V. Fluids (Saline and Dextrose). Intravenous Solution (IV) Manufacturing Business with Blow-Fill-Seal (BFS) Technology.

Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Another cause is blood loss, which causes problems both because people lose blood products, and because they experience a loss in fluid volume. Electrolyte levels in the blood can also become unstable as a result of rapid changes in fluid volume, in which case intravenous fluids can be used to restore the balance. Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Many companies manufacture packaged intravenous fluids, as well as products which can be mixed with sterile water to prepare a solution for intravenous administration. Intravenous fluids can be broken into two broad groups. Crystalloids such as saline solutions contain a solution of molecules which can dissolve in water. When crystalloids are administered, they tend to create low osmotic pressure, allowing fluid to move across the blood vessels, and this can be linked with edema. Colloids contain particles which are not soluble in water, and they create high osmotic pressure, attracting fluid into the blood vessels. Blood is an example of a commonly administered intravenous colloid. Infusion therapy as a basic toll of modern medical care enables the physician to restore and stabilize homeostasis states quickly and completely. In nursing homes and hospital where patients are suffering from acute dehydration or considerable debilitating conditions, the intra venous fluids are used as I.V. drips. The basic function of I.V. fluids is to replenish the body fluids. Although there are a number of I.V. fluids but generally three types of I.V. fluids are used in hospitals as I.V. drips. Uses and Applications There are main ranges of application of highly specialized intravenous infusion solutions: • Treatment of discarded water and electrolyte metabolism, especially in severe cases. • Therapy of acid base in balances. • The volume substitution and volume replacement in surgery of accident victim suffering blood loss. • Paratral nutrition for severally ill and post-operative patients. • Aqueous isotonic injection (5%) of dextrose is given as intravenous injections to increase the column of circulating blood in the shocks and haemorrhages and to counteract dehydration. When it is desired to replace excessive salt loss also glucose is injected along with sodium chloride. Intravenous fluids can also be used as a route of medication administration. If a doctor wants to delI.V.er a small amount of medication over an extended period of time, it can be dissolved in a bag of intravenous fluids and set on an infusion pump which delivers the medicated fluid directly into the blood. They are also commonly used to assist with surgical recovery; people who receive fluids after surgery tend to experience better recovery than people who do not. Intravenous Fluids Market is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast. The growth of the global intravenous solutions market is driven by several factors. The increasing incidence of gastrointestinal disorders, diabetes, and cancer is one of the major factors that are expected to increase the rate of adoption of intravenous solutions among consumers. The rising popularity of intravenous vitamin C therapy in cancer treatment is one of the major trends in the intravenous solutions market. The intravenous vitamin C solution has been observed to have an increased toxicity to cancer cells and improve the patients' quality of life. Intravenous fluids are extensively used to treat electrolyte imbalances, maintain fluid balance, and replace fluid losses. These fluids are dispensed in volumes ranging from 25-1,000 milliliters and are available in either plastic bags or glass bottles. A complete mixture of all essential nutrients is also available in multi-chamber bags, and these bags are gaining immense popularity among numerous end-users. The global Intravenous (I.V.) solutions market was valued at USD 6.9 billion in 2015 and is projected to grow at a CAGR of 7.8% over the forecast period. The emergence of this market is attributed to the fast growing geriatric population and prevalence of malnutrition in the elderly and pediatric population. Blow-Fill-Seal (BFS) Technology In blow-fill-seal (BFS) technology, which is a form of advanced aseptic manufacturing, the container is formed, filled, and sealed in one continuous, automated system. A primary advantage of this technology is reducing human intervention, which reduces the risk of microbial contamination and foreign particulates. BFS has long been used in liquid pharmaceutical applications, including small containers, such as ophthalmic and respiratory drug ampoules, as well as larger volume containers, such as saline or dextrose solutions. More recently, BFS technology has been expanding into injectable and into biologics, including vaccines and monoclonal antibodies (mAbs). Advantages of BFS Technology: • Blow-fill-seal technology enables the manufacture of preservative-free single-unit doses. PreservatI.V.es are recognized as potentially harmful to the sensitive mucosae of the eyes, nose, and lungs, so this is an enormous benefit to sensitive patients. • Another advantage of unit-doses is that they ensure that the patient takes the correct amount of product, especially when dealing with highly potent compounds, i.e. those therapeutically active at a low concentration. • Sterile unit-doses are portable and easy to use individually, excellent properties for today’s active lifestyles. Blow-fill-seal (BFS) single doses are an ideal solution for use in ophthalmology, respiratory diseases, rhinology, antisepsis and wound care. • Blow-fill-seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals. BFS is used for the filling of vials for parenteral preparations and infusions, eye drops, and inhalation products. Generally the plastic containers are made up of polyethylene and polypropylene. Polypropylene is more commonly used to form containers which are further sterilised by autoclaving as polypropylene has greater thermostability. • Blow Fill and Seal technology is mainly used for pharmaceutical solutions. The examples of pharmaceutical solutions that can be packaged are injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for dialysis, solutions for irrigation and solutions for hemofiltration. The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine. Thus this technology can be used to aseptically manufacture sterile pharmaceutical liquid dosage forms. The process is multi-stepped: first, pharmaceutical-grade plastic resin is vertically heat extruded through a circular throat to form a hanging tube called the parison. This extruded tube is then enclosed within a two-part mould, and the tube is cut above the mould. The mould is transferred to the filling zone, or sterile filling space, where filling needles (mandrels) are lowered and used to inflate the plastic to form the container within the mould. Following the formation of the container, the mandrel is used to fill the container with liquid. Following filling the mandrels are retracted and a secondary top mould seals the container. All actions take place inside a sterile shrouded chamber inside the machine. The product is then discharged to a non-sterile area for labeling, packaging and distribution. The process begins with the Extrusion of plastic granules in the form of a hot hollow pipe of molten plastic called a parison. The following step is the Blow moulding of the container from the plastic granule. The parison is closed between the mould, and the container gets formed either by blowing sterile compressed air or by vacuum or by using vacuum as well as blowing. The container assumes the shape of the cavity in the mould. The container thus produced is open from the top and in its top part, the plastic is still hot and in molten state until the subsequent steps of filling and container sealing. The subsequent step is filling of the formed container from the top, which is still open (and still in a “hot molten” state). Filling nozzles enter from the top of container and filling is done. Filling nozzles are specially designed and constructed to facilitate automatic cleaning and automatic sterilization. Additional functions of filling nozzles are to blow the bottles and also to provide an exhaust path for air in the container. The filling process can be carried out under a shower of sterile filtered air to avoid contamination during filling. The blower on the sterile air shower can have variable pressure which can be made to change automatically so as to maintain constant air pressure under various situations. The sterile air shower is validated at certain air pressure, and an automatic device can maintain the same pressure by automatically modulating the speed of the blower. The next step is sealing the top of the container, which is still open and in a hot molten state. The top gets pressed between head moulds and as a consequence, the top part of the container gets formed, sealed and at the same time, gets cooled. The result is a hermetically sealed container. The final steps are for De-flashing to remove the flash or scrap, trimming the containers and delivering the containers outside the machine. The whole process of extrusion, blowing, filling, sealing and removing scrap takes between 10 to 18 seconds depending upon the type and size of the container. The advantage of the Blow-Fill-Seal process is derived mainly from the fact that container is formed, quickly filled and sealed under protected environment automatically without human intervention. BFS Machine Professional normal saline I.V. fluids packaging machine is the latest production line with most advanced technology. It can automatically finish film feeding, printing, bag making, filling and sealing in one machine. This BFS line can be used to automatically fill 50-5000ml general solution, special solution, dialysis solution, parenteral nutrition, Antibiotics, Irrigation and Disinfectant solution etc. Features: 1. 100% film utilization: No waste edge between bags, reducing both material and energy consumption. 2. Special I.V. bag design: each bag saves 10mm film than others. 3. Reliable heating and welding system: Leakage rate less than 0.03%. 4. Quick changeover: 0.5-1 hour to switch from one size to another. 5. Stable transmission system: only needs 1 control system, 1 HMI and 1 operator. 6. Safe filling nozzle: No solution overflows, no particles generation. 7. Auto faulty rejection system detected by the machine. 8. Production line length is reduced by 1/3, both workshop and air conditioning and cleaning area are reduced by 1/3, greatly reducing the initial investment and future running cost. 9. Simple structure, more stable and reliable performance. Tags I.V. Fluid Manufacturing Industry, I.V. Fluids Manufacturing Project Report, I.V. Fluids Manufacturing Process, Project Report for I.V. Fluid Plant, I.V. Fluids Manufacturing Equipment, IV Fluids Manufacturing Project Report, I.V. Fluid Manufacturing Plant in India, I.V. Fluids Manufacture, I.V. Fluid Production Plant, I.V. Fluid and Dialysis Solution Manufacturing, Project Report on Dextrose Saline (IV Fluid) Production, I.V. Fluids Production, I.V. Fluid Manufacturing Unit, IV Fluid Manufacturing Business, Pharma Manufacturing Unit in India, Pharmaceutical Company, Intravenous Fluid Production, Project Report on I.V. Fluid, IV Fluid Manufacturing Unit in India, I.V. Fluids Manufacturing Process, I.V. Fluids Manufacturing Equipment, Manufacturing Plant for I.V. Fluid, I.V. Fluid Manufacturing Machine, I.V. Fluids Manufacturing Project Report, IV Fluid Manufacturing Business, Manufacturing Plan of Intravenous Fluid, How to Start I.V. Fluid Production Business, I.V. Solution Manufacturing with BFS Technology, Blow-Fill-Seal Technology, Saline and Dextrose Fluid (IV Fluid) BFS Technology, Blow Fill Seal(BFS) Technology, Project Report on I.V. Fluid (BFS Technology), I.V. Fluid with BFS, Blow-Fill-Seal Machinery, I.V. Fluid Manufacturing using Blow–Fill–Seal Technology, I.V. Fluid Manufacturing project ideas, Projects on Small Scale Industries, Small scale industries projects ideas, IV Fluid Manufacturing Based Small Scale Industries Projects, Project profile on small scale industries, How to Start I.V. Fluid Manufacturing Industry in India, I.V. Fluid Manufacturing Projects, New project profile on I.V. Fluid Manufacturing industries, Project Report on IV Fluid Manufacturing Industry, Detailed Project Report on IV Fluid Manufacturing, Production of Intravenous Sugar Solution (Dextrose Solution), Saline and Dextrose Fluid (iv Fluid) BFS Technology, Production of Intravenous Sugar Solution, Project Report on I.V. Fluid Manufacturing, Pre-Investment Feasibility Study on IV Solution Manufacturing with BFS Technology, Techno-Economic feasibility study on I.V. Solution Manufacturing with BFS Technology, Feasibility report on I.V. Solution Manufacturing with BFS Technology, Free Project Profile on I.V. Solution Manufacturing with BFS Technology, Project profile on I.V. Solution Manufacturing with BFS Technology, Download free project profile on IV Solution Manufacturing with BFS Technology, Industrial Project Report, Project consultant, Project consultancy, Business guidance to clients, Startup Project for I.V. Solution Manufacturing with BFS Technology, Production of I.V. Fluids (Saline and Dextrose), Intravenous Solution (IV) Manufacturing Business with Blow-Fill-Seal (BFS) Technology
Plant capacity: 48,000 Bottles/Day 500 ml each bottlePlant & machinery: 253.00 Lakhs
Working capital: N/AT.C.I: Cost of Project 834.00Lakhs
Return: 29.00%Break even: 52.00%
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I.V. Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Fluids are given when someone's body fluid volume falls. There are a number of things which can cause a drop in fluid volume. Vomiting and diarrhea are a classic example, which is why people are encouraged to drink fluids when they are sick, to keep their fluid volume stable. Intravenous fluids can also be used as a route of medication administration. The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn. India has the world's third largest active pharmaceutical ingredients (API) for the industry valued at a little less than USD 2 bn. These new business streams would help growth in future earnings. Intravenous (IV) fluids market in India is around Rs. 3,000 crore growing at healthy rate of around 15-20 per cent a year due to its essential requirement in nature. Which facilitates the development of new technologies and ensure a high quality product. Few Indian major players are as under • Abaris Healthcare Pvt. Ltd. • Ahlcon Parenterals (India) Ltd. • Axa Parenterals Ltd. • Infutec Healthcare Ltd. • Kokad Pharmaceutical Laboratories Ltd. • Parenteral Surgicals Ltd. • Punjab Formulations Ltd.
Plant capacity: I.V. Fluid (500 ml.): 48000 Bottles /DayPlant & machinery: Rs 252 lakhs
Working capital: N/AT.C.I: Cost of Project: Rs 833 lakhs
Return: 29.00%Break even: 52.00%
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Ready Mix Coating Powder Used for Coating of Pharmaceuticals Tablets for Regular fill Coating and Functional Film Coating

In pharmaceutical drug delivery of solid oral dosage forms film coatings are frequently applied. The motivation for coating dosage forms range from cosmetic considerations (colour, gloss), improving the stability (light protection, moisture and gas barrier) and making it easier to swallow the tablet. In addition, functional coatings can be used to modify the drug release behaviour from the dosage form. A film coating is a thin polymer-based coat applied to a solid dosage form such as a tablet. The thickness of such a coating is usually between 20-100 µm. The Indian excipient market is expected to grow at the rate of 10–12 percent until 2020. the excipients are priced at 5–7 percent lesser in India v Which facilitates the development of new technologies and ensure a high quality product. Few Indian major players are as under • A D C L Drugs & Chemicals Ltd. • Anmol Drugs & Pharmaceuticals Ltd. • Avinash Drugs Ltd. • Beryl Drugs Ltd. • Bio-Caps India Ltd. • Bio-Ethicals Pharma Ltd. • Biochem Pharmaceutical Inds. Ltd
Plant capacity: Regular Film Coating Powder: 400 Kgs/Day Functional Fim Coating Powder: 400 Kgs/DayPlant & machinery: 19 lakhs
Working capital: -T.C.I: Cost of Project: Rs 172 lakhs
Return: 28.00%Break even: 59.00%
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Investment Opportunities in Calcium Gluconate Manufacturing Industry

Investment Opportunities in Calcium Gluconate Manufacturing Industry. Production of Calcium Gluconate. The global market for calcium gluconate is likely to expand due to the escalation in the demand from different end-use industries especially from food and beverages and pharmaceutical sectors. Calcium gluconate, a mineral supplement, is produced by the neutralization of gluconic acid with calcium carbonate or lime. It is used for treating conditions resulting from calcium deficiencies. These conditions include: hypocalcemia related to hyperparathyroidism, hypocalcaemia tetany, and hypocalcaemia associated with rapid growth or pregnancy. Besides its use as an active ingredient in medicines, it is also widely used in numerous food products, where it serves the role of a nutrient supplement. Calcium gluconate is a source of calcium in different varieties of foods and beverage, including: soft drinks, milk, bottled waters, juices, soy products, dairy products, confectionery, and baked goods. Calcium gluconate is extensively used in the treatment of Calcium deficiency, both for oral and parenteral administration. For Calcium therapy, Calcium gluconate is a well-established and most accepted drug in the medical field. Calcium in its ionic form has been shown to be an excellent therapeutic agent for the treatment of diseases caused and aggravated by deficiency of Calcium in the body. Calcium gluconate is being used as Tablets, intramuscular injections and as syrups. Calcium Gluconate forms a definite compound with Boric acid called Calcium Boro Gluconate which is more popular in the veterinary medical field. Calcium Boro Gluconate is used for the treatment of milk fever of milking cows. Uses: • Calcium gluconate is used to prevent and to treat calcium deficiencies. • Calcium gluconate may also be used for purposes not listed in this medication guide. • Calcium gluconate is being used as Tablets, intramuscular injections and as syrups. • It is used for treating conditions resulting from calcium deficiencies. Calcium Gluconate is used in the treatment of: • Heart Arrest • Hyperkalemia • Osteoporosis, Postmenopausal • Tetany Calcium Gluconate Market The global market for calcium gluconate is projected to grow as a result of the mounting demand from different end-use industries with the highest demand expected from pharmaceutical and food and beverages. Additionally, sunrise industries, such as nutraceuticals, have also largely stirred up demand for calcium gluconate globally. It is a major ingredient in various calcium-based health supplements. The global market for calcium gluconate can be segmented broadly based on application, end use, as well as the form available. Based on the end use, the market for calcium gluconate can be further segmented into: emulsifier, bulking agent, and thickening agent. Similarly, on the basis of application, the calcium gluconate market can be further bifurcated into: food & beverages, pharmaceuticals, and nutraceuticals. The mineral supplement is available in the following forms on the commercial market: gum, powder, and liquid. Calcium gluconate market has dominantly driven by its importance in medical treatment such as Calcium therapy. Its extensive use in injection and pharmaceutical medicines has increased the market demand. However, the various application markets with a significant demand for food and beverages are another major driver. Calcium gluconate is a biodegradable product, which has become additionally important for being environment-friendly. Despite its drivers, there are certain factors that affect the market growth such as the adverse health of calcium gluconate. Excessive consumption of calcium gluconate results in nausea, vomiting, constipation, decreased appetite and dry mouth that acts as a restraint for the market. Moreover, the different food regulatory constraints that hinder the product formulation and labeling requirements are also affecting the market. Global calcium gluconate market is expected to grow owing to increasing demand from end-use industries such as pharmaceutical and food & beverages. Sunrise industries like the nutraceutical industry has also largely impacted the global calcium gluconate market, as it finds itself as major ingredient in multiple calcium based health supplements. Increase in the demand for health supplements from the health conscious consumers has largely driven this market globally. More than 75% of Americans are calcium deficient, and more than one in 10 Americans either has, or is at risk of developing, osteoporosis or other bone diseases. Geographically, the global calcium gluconate market can be classified based on seven regions: Latin America, North America, Eastern Europe, Western Europe, Asia Pacific excluding Japan (APEJ), Japan, and the Middle East and Africa (MEA). The Asia Pacific region is projected to witness the highest growth thanks to increasing demand from the numerous end-use industries here. In addition, the growing government spending on infrastructure development will also help fuel the market’s growth through the forecast period. Tags Production of Calcium Gluconate, Manufacture of Calcium Gluconate, Calcium Gluconate Production, Preparation of Calcium Gluconate, Calcium Gluconate Manufacturing Plant, Calcium Gluconate Manufacture, Calcium Gluconate Industry, Manufacturing of Calcium Gluconate, How to Start Production of Calcium Gluconate, How to Start Calcium Gluconate Manufacturing Industry, Calcium Gluconate Manufacturing Business, Calcium Gluconate Production Plant, Calcium Gluconate Manufacturing Unit, Starting Your Own Calcium Gluconate Manufacturing Business, Production Process of Calcium Gluconate, Calcium Gluconate Production Project Ideas, Projects on Small Scale Industries, Small Scale Industries Projects Ideas, Calcium Gluconate Production Based Small Scale Industries Projects, Project Profile on Small Scale Industries, How to Start Calcium Gluconate Production Industry in India, Calcium Gluconate Production Projects, New Project Profile on Calcium Gluconate Production Industries, Project Report on Calcium Gluconate Production Industry, Detailed Project Report on Calcium Gluconate Production, Project Report on Calcium Gluconate Production, Pre-Investment Feasibility Study on Calcium Gluconate Production, Techno-Economic Feasibility Study on Calcium Gluconate Production, Feasibility Report on Calcium Gluconate Production, Free Project Profile on Calcium Gluconate Production, Project Profile on Calcium Gluconate Production, Download Free Project Profile on Calcium Gluconate Production, Industrial Project Report, Project Consultant, Project Consultancy, Startup Project for Calcium Gluconate Production
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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