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Pharmaceutical, Drugs, Fine Chemicals, Bulk Drug Intermediates, Pharmaceutical Drugs, Pharma Drug Ingredients Intermediates, Drug Intermediates, Speciality Chemicals, Raw Materials, Fine and Specialty Chemicals Intermediates, Pharmaceutical Bulk Drugs

Indian drugs and pharmaceutical industry has advanced perceptibly and is getting ready  for the new patent regime and  to withstand global competition, which is expected to be unleashed by new winds of liberalisation - a new era of liberalisation - much different from what was ushered in since the conclusion of the Uruguay Round and the establishment of the World Trade Organisation.

The industry has been expanding at annual rates ranging between 8 to 10% (against global growth rate of 6%).  According to a study  by McKinsey, Vision 2010, the domestic pharmaceutical industry could attain a size of  $25 billion (Rs 1200 billion) by 2010 by focusing on two areas: first, innovation-led research, development and new drug discoveries; and second, information technology-led remote sales and marketing.  The market for bulk drugs and formulations had increased from about Rs 103  billion in 1990-91 to an estimated Rs 435  billion at the end of 2003-04.  The prices of Indian essential drugs are among the lowest in the world. Apart from strides made by the industry in the last half-a-century, lower production cost due to reverse engineering and low R&D outlays has been a major factor in keeping the prices under check.

The global pharmaceutical industry is estimated at $ 300 billion, not all representing cross-border trade.  India's measly share of $ 1.5 billion in global trade represents an untapped potential. Under the regime of economic liberalisation underway since early 1990s, the drugs and pharmaceutical sector witnessed initiatives at fresh investment in the sector. Nearly 1735 investment proposals of the order of around Rs 166  billion were initiated. The foreign collaboration proposals approved numbered around 425 with a foreign direct investment  (FDI) component of over Rs 25 billion. The pharmaceuticals have figured high on the export front. In 2001-02,  the sector was  estimated to have registered a growth of 17.6% at around Rs 20.3 billion.

In the wake of economic liberalisation, many a  overseas players  returned or contemplated returning to India. These include Ivox Corp (USA),  Taro Pharmaceuticals (Israel) and Merck (USA). These are out either to set shop or looking for acquisitions in India. Hexal AG of Germany has established a liaison office in India. MILLIONCs like Rocha, Bayer, Aventis and Chiron are making India a regional hub for bulk drugs. 

The Export Import Bank of India (Exim Bank) had  doubled its corpus for the pharmaceutical industry to Rs 2 billion as a result of increased activity in the industry, especially in the external sector. The fund is used for the development and commercialisation of the new products and applications, significant improvement in the existing design of  products, setting up and expansion of pilot plants, research studies for obtaining regulatory approvals, cost of filing and managing international patent and R&D Centres.

It needs, however, to be recognised that the presence  of small scale manufacturers has resulted, on the one hand,  in a highly fragmented industry, and on the other, it has made it possible to supply a near 100,000 drugs including vitamins, antibiotics, antibacterials, cardio-vascular and other essential drugs. These account for nearly 37% of the market.  While each of about 80% of the manufacturers has annual sales below a billion rupees, top ten companies are known to control over 30% of the market. At present there are more than 20,000 players in the country.

The major players are: Alembic Chem, Aurobindo Pharma, Cipla, Dr. Reddy's, FDC, IPCA Labs, Jagsonpal Pharma, J.B. Chemicals, Kopran, Lupin Labs, Lyka Labs, Morepan Labs, Nicholas Piramal, Ranbaxy Labs, Sun Pharma, Themis Medicare, GlaxoSmithkline, Astrazeneca, Aventis, E-Merck, Torrent Pharma, TTK Healthcare, Unichem Labs,  Wockhardt  and  Zandu Pharma.  Until recently, only a few of the Indian companies had gone into any serious R&D activity. Much of the effort was directed to affordable analogue research. The R&D level in the country is low with even well-placed pharma companies spending less than 2% of turnover on R&D. MILLIONCs are known to contribute as much as 10% or more of their turnover to R&D.  While India is very strong in process chemistry, biology and applied bio-chemistry, initiatives at all levels - government, academia, private sector - involving heavy financial outlays, are called for.

Ayurveda continues to remain a preferred system of medicine for a vast segment of population in the country. The country has over 400,000 registered practitioners of the Indian system of medicine. Around 170 institutes properly affiliated to various universities impart under- or post-graduate courses each year. These institutes churn out some 5,500 fresh practitioners. The practitioners are supported by 12,000 dispensaries and 2,100 beds available for ayurveda treatment countrywide. The emerging biotechnology sector has already taken by storm and is offering sops to states to make these as the thriving ground for the highly potential segment in medicare.

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Thiourea (Using Carbon Disulphide)

Thiourea is an organosulfur compound with the formula SC(NH2)2. It is structurally similar to urea, except that the oxygen atom is replaced by a sulfur atom, but the properties of urea and thiourea differ significantly. Thiourea is a reagent in organic synthesis. "Thioureas" refers to a broad class of compounds with the general structure (R1R2N) (R3R4N)C=S. Thioureas are related to thioamides, e.g. RC(S)NR2, where R is methyl, ethyl, etc. Thiourea is an organic compound of carbon, nitrogen, sulfur and hydrogen, with the formula CSN2H4 or (NH2)2CS. It is similar to urea, except that the oxygen atom is replaced by a sulfur atom. The properties of urea and thiourea differ significantly because of the relative electro negativities of sulfur and oxygen. Thiourea is a versatile reagent in organic synthesis. "Thioureas" refers to a broad class of compounds with the general structure (R1R2N) (R3R4N)C=S. Thioureas are related to thioamides, e. g. RC(S)NR2, where R is methyl, ethyl, etc. Thiourea is originated from laburnum shrubs and is also a natural metabolite of the fungi Verticillium alboatrum and Bortrylius cinerea with no significant emissions into the air from the industrial use of thiourea as a catalyst in the synthesis of fumaric acid, diazo paper, or metal polish, whereas releases to surface water are unclear. Based on end-user industry, the thiourea market can be segmented into textile, pharmaceuticals, agriculture, mining, rubber, chemical, and paper. Agriculture is likely to remain the major end-user industry segment of the thiourea market during the forecast period. Thiourea is used as an effective pesticide in crop protection. It helps boost crop productivity in the field. Use of thiourea in the pharmaceutical industry is also expected to increase significantly between 2017 and 2025. In the pharmaceutical industry, thiourea is employed as an intermediate for making thiazole and drugs inhibiting for thyroid disease. The pharmaceutical segment is anticipated to exhibit significant CAGR during the forecast period. Agriculture is likely to remain the major sector for the growth of thiourea market. While the pharmaceutical segment is expected to show substantial growth during the forecast period. The increase in investments in the growing agriculture and pharmaceutical industries creates opportunities for the global thiourea market. However, toxicity related to thiourea has hampered the consumption of thiourea in the market which might act as a restraining factor for the growth of the thiourea market globally.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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Ark of Ajwain, Pudina, Saunf & Gulab (Extracts of Carom Seeds, Mint, Fennel & Rose)

Ajwain (Carom Seeds) Ajwain's small, oval-shaped, seed-like fruits are pale brown schizocarps, which resemble the seeds of other plants in the Apiaceae family such as caraway, cumin and fennel. They have a bitter and pungent taste, with a flavor similar to anise and oregano. They smell almost exactly like thyme because they also contain thymol, but they are more aromatic and less subtle in taste, as well as being somewhat bitter and pungent. Even a small number of fruits tends to dominate the flavor of a dish. Pudina (Mint) Mint or Pudina is a common ingredient used to flavor dishes all around the world. It is also a common ingredient in cosmetic products thanks to the excellent skin care benefits that it offers. It is often found in moisturizers, cleansers, conditioners, lip balms, and even shampoos. The global mints market is expected to reach USD 7.76 billion by 2023 registering a healthy CAGR of 4.2% during the forecast period. About 397million Kg of mints consumed in 2016, which is growing at a stable growth rate. Rising sugar-free chewing gum sale possess a healthy competition to mint market in the recent year with the introduction of hybrid products composed of mint and gum. Consumer preference for mint remains high as compared to chewing gum due to its oral benefit and low sugar content. Innovation in products with various flavors drives the mint market. Impulse purchase, convenient pack, innovation in products has fueled the mints market growth. Saunf (Fennel) Fennel (Foeniculum vulgare) is a flowering plant species in the carrot family. It is a hardy, perennial herb with yellow flowers and feathery leaves. It is indigenous to the shores of the Mediterranean but has become widely naturalized in many parts of the world, especially on dry soils near the sea-coast and on riverbanks. The global fennel seeds market to grow at a CAGR of 14.08% during the period 2017-2021. The primary reason for the growth of the global fennel seeds market is the increasing awareness about the health benefits of fennel seeds. It aids in digestion, reduces obesity, helps with menstrual problem, helps eliminate bad breath, and relieves chronic coughs. The growth in organized retail increases the product availability for consumers, which drives the market. The global market for fennel seeds is dependent on the factor of demand side. Owing to its flavor and aroma. Furthermore, the innovations pertaining to the personal care industry have further inspired the growth of the international market for fennel seeds. Fennel seeds are found to be relaxing and soothing agent in the aromatherapy. Owing to the availability of products of organic fennel seeds, it has become possible for the consumers who prefer organic ingredients, to purchase the product. This has further impacted the growth of the said market positively. The fennel seeds market come with a wide range of applications in the market, particularly as seasoning and flavor ingredient. It is also used soft drinks and beverages. Such widespread usage is boosting the growth of the market. The increasing demand for aromatherapy is one of the latest trends that will gain traction in the fennel seeds market in the coming years. Gulab (Rose) Rose plant is globally popular and culturally significant flowering plant that is cultivated across the world, with many varieties being native to Asia. Rose extracts are medically or therapeutically significant components that are derived from petals, fruits, leaves and seeds of the rose plant. Each of these types of extracts has been part of traditional medicines but are finding increasing commercial applications. In the case of rose extract, a high presence of vitamin C is a major driver for its adoption in the food and beverage industry. For instance, it has been observed that rose contain over 50% more vitamin C than oranges. In this context food fortification, which is the addition of one or more beneficial ingredients to food and beverage products, is an important opportunity for rose extracts. Rose extracts is also gaining prominence for its role in the treatment of osteoarthritis, which is a condition that affects bone and joint health in the elderly population. The Rose Extract market is segmented on the basis of type, application, and form. The global rose extract market is primarily driven by increasing use of rose petal oil for the treating health conditions in the geriatric population. Moreover, increasing preference of consumers for natural and organic ingredient products is expected to favor the market growth. in addition to this, rose oil are the safe and harmless alternatives to allopathic solutions is also pushes the market growth. However, the presence of a high number of substitute products at competitive prices is hampering the market growth.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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Empty Gelatin Capsules

Gelatin capsules, informally called gel caps or gelcaps, are composed of gelatin manufactured from the collagen of animal skin or bone. Capsules offer a viable alternative to tablets as an oral delivery of therapeutic compounds. Empty capsules are oral dosage forms, which based on the type of manufacturing material, come in variety of sizes and colors such as pearl capsules and flavored capsules. There are various types of capsules such as soft gelatin capsules, hard gelatin capsules, sustained release capsules, enteric coated capsules, and rectal capsules. Soft and hard gelatin capsules are widely used empty capsules. Empty capsules are available in five sizes, which includes 00, 0, 1, 2, and 3 and each sized capsule can hold different quantity of active pharmaceutical ingredients. These capsules are differentiated on the basis of the amount of active pharmaceutical ingredient they can hold. For instance, 0 sized capsule can hold up to 500 mg and 3 holds about 200 mg of active pharmaceutical ingredient. Gelatin is widely used in the empty capsules market due to its softness, lack of a notable odor or taste, and stability across a wide temperature range. However, growing opposition to animal-derived gelatin in economically crucial markets such as India, where vegetarianism is the norm, is likely to lead to significant product development in the global empty capsules market in the coming years. The global empty capsules market is projected to reach USD 2.79 billion by 2023 from USD 1.95 billion in 2018, at a CAGR of 7.4%. The growing adoption of capsule formulations among the growing geriatric population, growth of the pharmaceutical market along with the increasing R&D activities & clinical trials, and advancements in capsule delivery technologies are some of the major factors driving the growth of the market. The empty capsules market is a key part of the global pharmaceutical industry and is likely to exhibit steady growth in the coming years due to the rapid proliferation of the pharmaceuticals sector in developing regions. Empty capsules present the perfect way to deliver medication of various kinds, which has imparted them universal utility across the pharmaceuticals industry and the upward trajectory of all aspects of the healthcare sector is likely to remain a vital driver for the market in the coming years. The demand for capsules is growing on account of the mounting consumption of medicines worldwide. This trend augurs well for the global empty capsules market, where growth has thus far been driven by the demand for both nongelatin and hard gelatin capsules. The changing demographics of the world have necessitated the greater production of medicines to treat various kinds of diseases. Capsules, being among the most versatile forms of administering drug doses, are thus expected to be consumed in larger volumes over the next few years.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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Disposable Plastic Syringes

Disposable Syringes are being used by doctors to inject medicines through intravenous or intramuscular ways for the treatment of diseases & also by research & development personnel. Disposable syringes are made of plastic material and are used in the field of medical and veterinary science. The manufacture of plastic syringes has been developed to such a degree that the products now satisfy the requirements and standards set by Hospital and physicians. Disposable syringes are the dominating market with a CAGR of around 6% over the forecast period i.e. 2016-2024 because disposable syringes are used only once ensuring the safety of patients. On the basis of material, glass syringe is dominating the segment and is expected to reach a value of USD 15 million by 2024 because they can be sterilized and reused. The syringes market is expected to reach USD 15.99 Billion by 2021 from USD 10.56 Billion in 2016, at a CAGR of 8.7% during the forecast period. Thus, due to demand it is best to invest in this project. Few Indian major players are as under • Albert David Ltd. • Disposable Medi-Aids Ltd. • Hindustan Syringes & Medical Devices Ltd. • Lifeline Injects Ltd. • Lifelong Meditech Ltd. • Oyster Medisafe Pvt. Ltd. • Peekay Mediequip Ltd.
Plant capacity: Disposable Plastic Syringes 2 ml Size: 60 Boxes/Day Disposable Plastic Syringes 5 ml Size: 60 Boxes/Day Disposable Plastic Syringes 10 ml Size: 40 Boxes/DayPlant & machinery: Rs. 137 lakhs
Working capital: -T.C.I: Cost of Project: Rs 307 lakhs
Return: 13.00%Break even: 61.00%
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IV Fluids (BFS Technology)

Intravenous fluids are fluids which are intended to be administered to a patient intravenously, directly through the circulatory system. These fluids must be sterile to protect patients from injury, and there are a number of different types available for use. Intravenous fluids can also be used as a route of medication administration. The market for Intravenous (IV) Solution is expected to reach USD 11,511.2 million by 2022 and is expected to grow at a CAGR of 7.69% during the forecast period 2016-2022. The factors which drive the growth of the market are the rising prevalence of chronic diseases, rising acceptance of vitamin C intravenous treatment therapy to treat colorectal cancer. Entrepreneurs who invest in this project will be successful.
Plant capacity: IV Fluids (500 ml Bottle): 40000 Pcs/day Plant & machinery: Rs 2734 lakhs
Working capital: -T.C.I: Cost of Project: Rs 3712 lakhs
Return: 26.00%Break even: 48.00%
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Acyclovir

Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection. It can be taken by mouth, applied as a cream, or injected. Acyclovir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Acyclovir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. Acyclovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, inject able, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). The acyclovir market is segmented on the basis of types of herpes virus, mechanism of action, application, and region. On the basis of types of virus they are segmented into herpes simplex virus type I (HSV-1), herpes simplex virus type II (HSV-2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Based on mechanism of action, the market is segmented into nucleotide polymerase inhibitors, reverse transcriptase inhibitors, protease inhibitors, and others.
Plant capacity: -Plant & machinery: -
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Return: 1.00%Break even: N/A
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Cloxacillin

Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections. This includes impetigo, cellulitis, pneumonia, septic arthritis, and otitis externa. It is not effective for methicillin-resistant Staphylococcus aureus (MRSA). It is used by mouth and by injection. Cloxacillin is used to treat a wide variety of bacterial infections. This medication is a type of penicillin antibiotic. It works by stopping the growth of bacteria. Cloxacillin is a penicillin-like antibiotic used for treating bacterial infections of the skin, bone, heart valves, blood, lungs, etc. caused by susceptible bacteria. This medicine is not recommended for treating common cold, flu or other viral infections since it is not effective in treating them. Cloxacillin is a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. • Global Cloxacillin Market share assessments for the regional and country level segments • Global Cloxacillin Market share analysis of the top industry players • Strategic recommendations for the new entrants • Global Cloxacillin Market forecasts for a minimum of 4 years of all the mentioned segments, sub segments and the regional markets.
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Return: 1.00%Break even: N/A
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Amoxicillin

Amoxicillin is an antibiotic often used for the treatment of a number of bacterial infections. It may be used for middle ear infection, strep throat, pneumonia, skin infections, and urinary tract infections among others. It is taken by mouth, or less commonly by injection. Amoxicillin belongs to a group of drugs called the penicillins. They originate from a form of fungi called Penicillium fungi. Amoxicillin fights bacteria and stops them from growing by preventing them from forming cell walls. This kills the bacteria and eventually eradicates the infection. Amoxicillin is the generic form of the brand-name drug Amoxil, a drug used to treat bacterial infections. Doctors prescribe amoxicillin to treat infections caused by bacteria that are sensitive to the drug, including E. coli, staphylococcus, streptococcus, H. influenzae, and H. pylori. Amoxicillin is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection.
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Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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Ampicillin

Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. It may also be used to prevent group B streptococcal infection in newborns. It is used by mouth, by injection into a muscle, or intravenously. Like all antibiotics, it is not useful for the treatment of viral infections. Ampicillin is used to treat a wide variety of bacterial infections. It is a penicillin-type antibiotic. It works by stopping the growth of bacteria. Ampicillin comes as a capsule and a suspension (liquid) to take by mouth. It is usually taken three to four times a day, either half an hour before or two hours after meals. The length of your treatment depends on the type of infection that you have. Take ampicillin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ampicillin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Ampicillin is a broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections. The global ampicillin market is driven by factors such as new product innovations and increasing R&D investments by major players. Moreover, regulatory concerns to control the antibiotic resistance problem are also expected to drive the global ampicillin market. Rising geriatric population is one of the key drivers for the growth of the global ampicillin market.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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Aluminium Hydroxide Gel

Aluminium hydroxide is a typical antacid active. It can be used alone or in combination with magnesium hydroxide to obtain the desired acid neutralizing capacity (ANC). Aluminium hydroxide as an antacid is not exactly an Aluminium hydroxide (Al(OH)3). Aluminium hydroxide gels are amorphous in nature and contain carbonate in the gel structure. The presence of carbonate increases the reactivity of the Aluminium, allowing for its acid-neutralizing capacity and making it a more effective antacid. Aluminium hydroxide gels and powders are available worldwide and provides the consistent quality required for pharmaceutical use. Aluminium hydroxide, Al(OH)3, is found in nature as the mineral gibbsite (also known as hydrargillite) and its three much rarer polymorphs: bayerite, doyleite, and nordstrandite. Aluminium hydroxide is amphoteric in nature, i.e., it has both basic and acidic properties. Closely related are aluminium oxide hydroxide, AlO(OH), and aluminium oxide or alumina (Al2O3), the latter of which is also amphoteric. These compounds together are the major components of the aluminium ore bauxite. Aluminum hydroxide is used to treat heartburn, upset stomach, sour stomach, or acid indigestion. Aluminum hydroxide is also used to reduce phosphate levels in people with certain kidney conditions. Aluminum hydroxide may also be used for purposes not listed in this medication guide. The global aluminum hydroxide market is expected to witness a CAGR of approximately 4.6% during the forecasted period.Aluminum hydroxides find application as fire retardants in polymer applications, as these compounds address the need for safety, durability, and insulation in many applications. Aluminium hydroxide (Gel) I.P. is used as an antacid and protective in the treatment of peptic ulcers. It is also used as astringent & antiseptic in cases of marked hyper acidity. It is used externally as a mild astringent and desiccant, and internally as an antacid and protective agent. Aluminium hydroxide is generally used in combination with other similar chemicals like Magnesium hydroxide & Magnesium trisilicate in the form of powder or paste, depending upon the final product i.e. tablet or suspension. Global Aluminum Hydroxide Gel Market is expected to gain a positive CAGR in the forthcoming period. Aluminum hydroxide gel is a naturally occurring mineral comprising three layers namely polymorphs, bayerite, doyleite&nordstrandite. Aluminum hydroxide gel is also known as gibbsite. Gibbsite possess a typical metal hydroxide structure comprised with hydrogen bombs.
Plant capacity: -Plant & machinery: -
Working capital: -T.C.I: -
Return: 1.00%Break even: N/A
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