Home » Profiles » 7 Aminocephalosporanic Acid (7 Aca) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

7 Aminocephalosporanic Acid (7 Aca) - Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities

7 ACA or 7 Aminocephalosporanic acid is made from Cephalosporin C and is a key intermediate for synthesizing cephalosporin antibiotics, the B lactam antibiotics family. 7 ACA is a starting compound for the production of various semi-synthetic cephalosporins of different generations. These compounds are made by modification of the side chains at positions 3 and 7 of 7-aminocephalosporanic acid (7 ACA). It is used to produce many cepholosporins pharmaceutical bulks, such as cefazolin sodium, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, ceftazime sodium, cefuroxime sodium and so on. Originally, the commercial processes were based on solvent extraction. 7 Aminocephalosporanic acid (7 ACA), until recently it has been produced by chemical deacylation of the natural antibiotic cephalosporin C. The disadvantage of this method is multiple steps, low yield, use of various organic solvents and treatment of a lot of toxic waste. Alternatively, 7 ACA can be produced by a simpler and more environmentally sound process using a bio-catalytic method based on DAAO and glutaryl hydrolase for enzymatic deacylation of CPC to 7 ACA. However, few enzymes capable of this direct deacylation have been discovered, probably because of the unusual nature of the D aminoadipyl side chain of cephalosporin C. Enzyme engineering is a fast growing application in the pharmaceutical market. Cephalosporin is defined as any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and is related to the penicillins in both structure and mode of action but relatively penicillinase resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum. They have the active nucleus of beta lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped. Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. The cephalosporins belong to the family of ? lactam antibiotics. These are named after the reactive moiety of the compounds, the ? lactam ring. In CPC, the four membered ? lactam ring is coupled to a six membered dihydrothiazine ring to form the nucleus, 7 aminocephalosporanic acid (7 ACA), and a side chain, ? aminoadipic acid, is coupled via an amide bond to the nucleus. The total world market for cephalosporins was estimated to be approximately 10 billion US$ in 2000, and ? lactam antibiotics in general accounting for over 65% of the world antibiotic market. According to IMS Health, cephalosporins as single preparation and in combination preparations are ranked 10 in the global drug sales in 2003 by an estimated sales of 8.3 billion US$, the highest ranking for any of the anti infectives classes. The size of the Indian pharmaceutical industry is poised to treble over the decade. It is expected to grow from about USD 6.3 billion in 2005 to about USD 20 billion by 2015, registering a CAGR of 12.3% and outperforming the global average of 9% in 2009 to 10. In terms of scale, the Indian pharmaceutical market is the 14th largest in the world but will graduate to the top 10 by 2015, overtaking Brazil, Mexico, South Korea and Turkey. India’s growth to a USD 20 billion market by 2015 indicates that the incremental growth of USD 14 billion over the coming decade is likely to be the third highest in the world. Demand for 7 ACA is principally determined by the market sales scale of downstream products. In terms of developing trend, ceftriaxone and cefazolin were two mainstream products of 7 ACA. Therefore, the market change in these two products directly affected the change in production-sales relations of 7 ACA. After dosage conversion, according to estimate the use of 7 ACA for making certriaxone accounted for 47.7% of the total consumption of 7 ACA. Obviously, ceftriaxone had become the biggest consumer of cephalosporins raw materials of 7 ACA series, followed by cefazolin. Not only ceftriaxone boosted morale, but cefotaxime, cefazolin sodium, cefoperazone sodium, cefoperazone sulbactam, ceftazidime, cefuroxime, etc were also the direct contributors of the family. At present, major players in the market include Shijiazhuang Pharmaceutical Group Co. Ltd., Fujian Fukang Pharmaceutical Group Co. Ltd., Shanxi Weiqida Pharmaceutical Group Co. Ltd. and Zhuhai United Labs Co. Ltd. At present there is no production of 7 ACA in the country and the demand is met by imports. There is a good scope for capacity creation in India. New entrepreneurs should venture into this sector.
Plant capacity: 150 MT/AnnumPlant & machinery: 1486 Lakhs
Working capital: -T.C.I: Cost of Project : 2167 Lakhs
Return: 64.00%Break even: 42.00%
Email Us | Add to Inquiry Add to Inquiry Basket

We can provide you detailed project reports on the following topics. Please select the projects of your interests.

Each detailed project reports cover all the aspects of business, from analysing the market, confirming availability of various necessities such as plant & machinery, raw materials to forecasting the financial requirements. The scope of the report includes assessing market potential, negotiating with collaborators, investment decision making, corporate diversification planning etc. in a very planned manner by formulating detailed manufacturing techniques and forecasting financial aspects by estimating the cost of raw material, formulating the cash flow statement, projecting the balance sheet etc.

We also offer self-contained Pre-Investment and Pre-Feasibility Studies, Market Surveys and Studies, Preparation of Techno-Economic Feasibility Reports, Identification and Selection of Plant and Machinery, Manufacturing Process and or Equipment required, General Guidance, Technical and Commercial Counseling for setting up new industrial projects on the following topics.

Many of the engineers, project consultant & industrial consultancy firms in India and worldwide use our project reports as one of the input in doing their analysis.

Information
  • One Lac / Lakh / Lakhs is equivalent to one hundred thousand (100,000)
  • One Crore is equivalent to ten million (10,000,000)
  • T.C.I is Total Capital Investment
  • We can modify the project capacity and project cost as per your requirement.
  • We can also prepare project report on any subject as per your requirement.
  • Caution: The project's cost, capacity and return are subject to change without any notice. Future projects may have different values of project cost, capacity or return.


About NIIR PROJECT CONSULTANCY SERVICES

Hide »

NIIR PROJECT CONSULTANCY SERVICES (NPCS) is a reliable name in the industrial world for offering integrated technical consultancy services. Its various services are: Pre-feasibility study, New Project Identification, Project Feasibility and Market Study, Identification of Profitable Industrial Project Opportunities, Preparation of Project Profiles and Pre-Investment and Pre-Feasibility Studies, Market Surveys and Studies, Preparation of Techno-Economic Feasibility Reports, Identification and Selection of Plant and Machinery, Manufacturing Process and or Equipment required, General Guidance, Technical and Commercial Counseling for setting up new industrial projects and industry.

NPCS also publishes varies technology books, directory, databases, detailed project reports, market survey reports on various industries and profit making business. Besides being used by manufacturers, industrialists and entrepreneurs, our publications are also used by Indian and overseas professionals including project engineers, information services bureau, consultants and consultancy firms as one of the input in their research.

^ Top

Products & Services

Others

Contact Us

My Account

Help

Payment Options

  • Credit Cards
  • Debit Cards
  • PayPal
  • Net Banking - (All Major Indian Banks)

We Process

  • Cards

Google Search